Otsuka Pharmaceutical Company, Limited

Baylor College of Medicine

Hitmac (usa), Inc.

Yukihiko Nosé

Kazuhide Ohta

Toshiyuki Shinohara

Tadashi Motomura

Junji Takaba

Kuniyoshi Watanabe

Hiroshi Miyamoto

The invention provides a way of producing a natural immunologically active state in a person by subjecting him to an apheresis procedure with bioincompatible biomaterials for about one hour. To safely control the immunological shock induced by this procedure, the person is put under general anesthesia for about six hours, including the apheresis time and at least an additional five hours thereafter. This immunological activation is useful for treating malignant tumors and diseases related to immunosuppression, such as AIDS. The invention also provides for the use of an apheresis column containing a blood perfusion filter with bioincompatible materials for treating malignant tumors and infectious diseases.

Immunoactivation blood perfusion filter for the treatment of malignant tumors

The present invention provides an inflow cannula tip that is shaped to prevent suction with the ventricular wall and adapted to prevent platelet adhesion. In particular, the inlet portion of the cannula tip comprises two projections extending from the cylindrical body of the cannula tip with gaps between the projections. The projections may have beveled edges. The inlet portion of the cannula tip can accept blood flow from either the gaps in the side or from the bottom of the tip. Even if the edge of the cannula tip is close to or even touching ventricle wall, a suction condition will not result, as blood is allowed to flow through the gaps between the projections.

Cannula tip for a cardiac assist device

Growing community of inventors

Houston, TX, United States of America

Yukihiko Nosé