Kissei Pharmaceutical Co., Ltd.

Yukihiko Hotei

Hidetoshi Isawa

Masayuki Isaji

Hiromu Harada

Masaaki Takemura

Itaru Miyashita

Satoshi Akahane

Kiyoshi Kasai

Yoshinori Nonaka

Koji Kamata

Junichi Sonehara

Humiyasu Satoh

Hiroshi Kusama

Mitsuhiro Ichihara

Hideki Hujikura

The present invention provides pyrazole derivatives, uses thereof for medical purposes and so on. More particularly, the present invention relates to pharmaceuticals useful for the prevention or treatment of constipation, which comprise as an active ingredient 3-(3-{4-[3-(&#x3b2;-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenoxy}propylamino)-2,2-dimethylpropionamide, or a pharmaceutically acceptable salt thereof. The pharmaceuticals of the present invention exert an effect of increasing the frequency of bowel movement or the like, and are useful for the prevention or treatment of constipation.

Pyrazole derivative and use thereof for medical purposes

The present invention provides ethyl (&#x2212;)-2-[4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-2,5-dimethylphenoxy]acetate hydrochloride, crystalline forms thereof and pharmaceutical compositions containing them, which have excellent &#x3b2;-adrenoceptor stimulating effects, therapeutic effects on pollakiuria or urinary incontinence and storage stabilities and are useful as a medicament.

Crystals of hydroxynorephedrine derivative

Polyphenylene ether resin

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Azumino, Japan

Yukihiko Hotei