Mitsui Norin Co., Ltd.

Chinese Academy of Medical Sciences

Other

University of London

Matsushita Seiko Co., Ltd.

Epitome Pharmaceuticals Limited

Mitsu Norin Co., Ltd.

School of Pharmacy

Yukihiko Hara

Shu Jun Cheng

De Chang Wang

Tadakatsu Shimamura

Paul T Wegener

Miwa Honda

Kazuo Okushio

Masao Hattori

Yoshikazu Tashiro

Peter William Taylor

Hajimu Yamamoto

Hoyoku Nishino

Paul Stapleton

Kazuo Nashimoto

Woong Shick Ahn

Hajime Asai

Ryota Seto

Tadashi Kitamikado

Kozo Nakamura

Mikio Nakayama

Hiroshi Hojo

Takashi Ando

Fumiko Hayakawa

Takahide Kimura

Yong Su Zhen

Slobodan Jovanovic

Insu P Lee

Yoshiomi Kosaka

Tateo Suzuki

Kanzo Sakata

Contemplated compositions and methods include a catechin at a concentration effective to inactivate SARS at least by a factor of 2 log 10 units when the formulation is applied to a surface. Preferably, the catechins are provided as a complex mixture, and most preferably as a near-native catechin preparation from green tea.

Durable biocides and disinfectants

Contemplated methods and compositions further increase susceptibility of sensitized MRSA against various antibiotic drugs. Most preferably, the MRSA is already sensitized with a galloylated catechin (e.g., ECG), and further sensitization is achieved by exposure to a non-galloylated catechin (e.g., EC), and most preferably the corresponding non-galloylated catechin.

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Compositions and methods are directed to covalent adducts between reducing agents and optionally substituted 3-hydroxyflavans, wherein the reducing agent is covalently bound to the B-ring of the 3-hydroxyflavan. Such adducts exhibit markedly increased stability towards oxidation as compared to the unmodified 3-hydroxyflavan. Particularly preferred 3-hydroxyflavans include green tea catechins, and especially EGCG, while especially preferred reducing agents include NAC and glutathione.

Stabilized 3-hydroxyflavan compositions and methods therefor

Contemplated compositions and methods utilize a combination of a polyphenol and a non-polyphenol cyclooxygenase-2 inhibitor. Preferably, the compositions are pharmaceutical and/or nutraceutical compositions and formulated in a dosage form and amount such that the polyphenol and the non-polyphenol cyclooxygenase-2 inhibitor are effective to reduce tumor incidence and/or multiplicity. In preferred aspects, the polyphenol is epigallocatechin gallate, epigallocatechin, epicatechin gallate, epicatechin, and/or a mixture of polyphenols isolated from a plant (e.g., polyphenon E), and the cyclooxygenase-2 inhibitor is rofecoxib, celecoxib, and/or valdecoxib.

Polyphenol coxib combinations and methods

Topical compositions, and particularly hydrophobic compositions include an essential oil in an amount effective to achieve substantially complete absorption of the composition in the skin without leaving a greasy residue. Especially preferred topical compositions may also include pharmaceutically active agents (e.g., polyphenol), additional essential oils, stabilizers, etc. In further preferred aspects, contemplated compositions may delay onset, or even prevent viral eruptions on the skin, and where applied as a lipstick, will increase reddening of the lip as well as reduce chapping.

Rapidly absorbing lipophilic skin compositions and uses therefor

The objective of the present invention is to provide a tea polyphenol composition that has reduced bitterness and astringency while containing catechins with high purity. The present invention provides a tea polyphenol composition, (A) comprising 85% by weight to 95% by weight of catechins, (B) wherein the catechins contains epigallocatechin gallate and gallocatechin gallate at a ratio of 65% by weight to 80% by weight and (C) wherein the ratio given by (epigallocatechin gallate+gallocatechin gallate)/(epicatechin+catechin+epigallocatechin+gallocatechin+epicatechin gallate+catechin gallate) is from 2 to 4.

Tea polyphenol composition and method for producing the same

A chewing gum which has a preventative effect against infection by influenza virus and inhibits dissemination of influenza virus. The chewing gum comprises adding at least 0.03 weight % of at least one tea polyphenol, for a chewing gum containing no organic acids; the chewing gum comprises at least 0.01 weight % of at least one tea polyphenol for a chewing gum containing at least one organic acid.

Chewing gum and production of the same

A method for a treatment of hyperplasia caused by papilloma virus, such as,, which comprises concomitantly topically and orally administering at least one tea catechin. Tea catechins do not involve the risk of side-effects and may be easily administered by the patients themselves.

Methods for treating hyperplasia

A method for a treatment of hyperplasia caused by papilloma virus, such as for treating Condyloma acuminata which comprises administering tea catechin. Tea catechins do not involve the risk of side-effects and may be easily applied to or inserted in the infected area by the patients themselves.

Method for treating hyperplasia

A method of increasing the activity of an antibiotic against methicillin resistant Staphylococcus aureus in a patient by administering to the patient the antibiotic in combination with a catechin and/or a theaflavin.

Method of strengthening antibacterial action of antibiotics

A method for treating cancer in a patient by administering to a patient an nti-cancer effective amount of an anti-metabolite selected from the group consisting of 1-.beta.-arabinofuranosylcytosine and 4-amino-4-deoxy-10-methylfolic acid and an anti-oxidant effective amount of a tea polyphenol compound selected from the group consisting of a tea catechin, a theaflavin and a combination of a tea catechin and a theaflavin.

Method of increasing the effectiveness of anti-metabolites

A composition for a treatment of HPV-infected Condyloma acuminata which comprises containing tea catechin as a main component. This medication has no danger of side-effects and may be easily applied to or inserted in the infected area by the patient themselves.

Composition for treating Condyloma acuminata

The present invention provides a medicated gargling cup with which it is possible to form a liquid for gargling effective for preventing cold by merely pouring water into the cup; an antiviral mask having a nonwoven fabric impregnated with a tea extract, which mask can be easily produced commercially and is capable of maintaining a high virus trapping performance, inactivating the trapped viruses and preventing them from being rescattered; an antiviral filter and an antifungal, antibacterial and antiviral filter comprising in laminations a dust collecting filter and a filter impregnated with a tea extract; an air cleaner and an air cleaner-humidifier comprising the antiviral filter.

Antiviral filter air cleaner impregnated with tea extract

A tyrosinase inhibiting agent acts specifically on tyrosinase to inhibit it; the effective component of this action being an inhibitor of tyrosinase consisting of tea polyphenols.

Reducing tyrosinase activity

A composition is provided for strengthening the acid resistancy of teeth containing at least one tea polyphenol, a fluoride such as fluorosodium and an aluminum salt, such as aluminum lactate or aluminum nitrate.

Growing community of inventors

Fujieda, Japan

Yukihiko Hara