Meiji Dairies Corporation

Meiji Milk Products Company, Limited

Yukie Suma

Masashi Yamada

Hiroto Suzuki

Bang Luu

Djalil Coowar

Masayuki Uchida

Yoshinori Asakawa

Natsuko Murata

Gaby Schmitt

Sachiko Okabe

Jean-Philippe Loeffler

Ellane Mohier

Philippe Chabert

Celine Junges-Girlanda

Florence Keyling

Florence Keyling-Bilger

Celine Girlanda-Junges

Bernadette Lutz-Bucher

Jose-Luis Gonzalez De Aguilar

Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): 

Indole derivatives substituted with long-chain alcohols and medicaments containing them

Provided is an indole long-chain alcohol, or a hydrate or an isomer thereof, represented by the following formula (I): wherein R, R, Rand Reach independently represent a hydrogen atom, a methyl group, an acetyl group, or a hydroxyl group, and n represents a number fromtoand a medicinal composition comprising the same. The indole long-chain alcohol (I) exhibits an excellent nerve growth promoting effect, as well as potent antioxidative and anti-tumor effects, and is therefore useful as a prophylactic and/or therapeutic agent for cerebral diseases including dementia diseases, and malignant tumors including brain tumors.

An indole derivative represented by the following general formula (1): 

Indole derivatives and drugs containing the same

The present invention provides a TNF-&#x3b1; production inhibitor containing a kavalactone as an active ingredient, which inhibitor has high safety, exerts an excellent effect of inhibiting TNF-&#x3b1; production, and is useful as a drug or an animal drug for preventing, ameliorating, or treating diseases such as cachexia attributed to cancer or infectious diseases, chronic rheumatoid arthritis, inflammatory diseases, osteoarthritis, systemic lupus erythematosus (SLE), rejection during bone marrow transplantation, multiple organ failure, AIDS, meningitis, hepatitis, and type-II diabetes. The present invention also provides a preventive, ameliorating, or therapeutic agent for diseases caused by abnormal production of TNF-&#x3b1;, the agent containing a kavalactone as an active ingredient.

TNF-&#x3b1; production inhibitor comprising kavalactone as an active ingredient

A preventive and therapeutic drug for a neurodegenerative disease containing, as an active ingredient, a cyclohexenone long-chain alcohol compound represented by formula (1) wherein each of R, R, and Rrepresents a hydrogen atom or a methyl group; and X represents a C10&#x2013;C28 alkylene group or alkenylene group. Since the compound of the present invention exhibits excellent neurite-extension ability and an inhibition effect on disorders caused by mutation in an SOD gene, it is useful as the active ingredient of a preventive and therapeutic drug for neurodegenerative diseases, inter alia, amyotrophic lateral sclerosis, and as the active ingredient of an inhibitory drug for disorders caused by mutation in an SOD gene.

Use of cyclohexenone long-chain alcohol for treating neurodegenerative diseases

The present invention provides a TNF-&agr; production inhibitor containing a kavalactone as an active ingredient, which inhibitor has high safety, exerts an excellent effect of inhibiting TNF-&agr; production, and is useful as a drug or an animal drug for preventing, ameliorating, or treating diseases such as cachexia attributed to cancer or infectious diseases, chronic rheumatoid arthritis, inflammatory diseases, osteoarthritis, systemic lupus erythematosus (SLE), rejection during bone marrow transplantation, multiple organ failure, AIDS, meningitis, hepatitis, and type-II diabetes. The present invention also provides a preventive, ameliorating, or therapeutic agent for diseases caused by abnormal production of TNF-&agr;, the agent containing a kavalactone as an active ingredient.

TNF-&agr; production inhibitor comprising kavalactone as an active ingredient

Described is a cyclohexenone long-chain alcohol represented by the formula (1):

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Tokyo, Japan

Yukie Suma