Yokohama City University

Chiome Beoscience Inc.

Yokohama City University and Chiome Bioscience Inc.

Chiome Bioscience Inc.

Yukie Sasakura

Shuichi Hashimoto

Koji Murakami

Hidetaka Seo

Yoshio Goshima

Naoya Yamashita

Fumio Nakamura

Naoki Takahashi

The present invention mainly addresses the problem of providing an antibody against semaphorin 3A protein, said antibody enabling effective prevention and/or treatment of a disease, in which Sema 3A protein participates, such as a neurodegenerative disease, autoimmune disease, inflammatory disease, cancer, infectious disease, etc. or disseminated intravascular coagulation syndrome. An anti-Sema 3A antibody comprising CDRs having specific amino acid sequences (SEQ ID NOS: 1-6, 60-62, 64-66, 68-70, 72-74, 76-78, 80-82, 84-86 and 88-90) enables effective prevention and/or treatment of a disease, in which Sema 3A protein participates, such as a neurodegenerative disease, autoimmune disease, inflammatory disease, cancer, infectious disease, etc. or disseminated intravascular coagulation syndrome and, therefore, remarkably ameliorates symptoms associated with such a disease.

Anti-semaphorin 3A antibody and treatment of Alzheimer's disease and inflammatory immune diseases using same

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Tokyo, Japan

Yukie Sasakura