Shionogi Company Limited

Hokkaido University

Yuki Tachibana

Akira Kugimiya

Takami Murashi

Masahiko Fujioka

Naohiro Onodera

Yoshiyuki Taoda

Kenji Nakahara

Shigeru Ando

Yuto Unoh

Shota Uehara

Yukiko Yamatsu

Michihito Sasaki

Koji Kasamatsu

Takahiro Suto

The present invention provides a compound exhibiting coronavirus 3 CL protease inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same. Furthermore, the present invention provides a crystalline form useful as an active pharmaceutical ingredient, and a pharmaceutical composition comprising the same. A compound represented by Formula: or a pharmaceutically acceptable salt thereof.

Triazine derivatives having virus replication inhibitory activity and pharmaceutical composition comprising the same

The present invention provides an sulfonamide derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases. A compound of the general formula (II): 

Sulfonamide derivative having PGD2 receptor antagonistic activity

The present invention provides an indolecarboxylic acid derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases. A compound of the general formula (I): 

Indolecarboxylic acid derivative having PGD2 receptor antagonistic activity

The present invention provides an indolecarboxylic acid derivative having DP receptor antagonistic activity and a pharmaceutical composition comprising the said compound as an active ingredient, and further a therapeutic agent for treating allergic diseases. A compound of the general formula (I):  wherein the ring A is an aromatic carbocyclic ring etc.; the ring B is a nitrogen-containing non-aromatic heterocyclic ring etc.; the formula of -X=X-X=X- is a formula of &#x2014;C(R)&#x2550;C(R)&#x2014;C(R)&#x2550;C(R)&#x2014; etc.; Xis C(R) or N; R, R, R, Rand Ris independently a hydrogen atom, a halogen atom etc; Ris a formula of -Z-Retc. wherein Z is alkylene etc., and Ris carboxy etc.; Ris optionally substituted alkyloxy etc.; Ris independently a halogen atom etc.; Ris independently optionally substituted alkyl etc.; Y is a single bond etc.; n is 0 etc.; q is 0 etc.; a pharmaceutically acceptable salt or a solvate thereof.

Growing community of inventors

Osaka, Japan

Yuki Tachibana