The Doshisha

National Center for Geriatrics and Gerontology

Yuki Shinzaki

Hachiro Sugimoto

Yoshikazu Inoue

Tetsuo Ota

Rie Tokizane

Yasuo Ihara

Tomohiro Miyasaka

Yohei Oe

Akihiko Takashima

Yoshiyuki Soeda

A tau aggregation inhibitor can sufficiently inhibit a tau protein from aggregating in cells. The inhibitor includes a 4-substituted catechol structure compound, having, at position 4 of its catechol ring, an electron-donating substituent R other than a hydrocarbon group, or a salt thereof. The 4-substituted catechol structure compound is preferably 4-aminocatechol or 1,2,4-benzenetriol. Examples of tauopathies to which this inhibitor is applicable include AD, Down's syndrome, frontotemporal dementia, cotricobasal degeneration (CBD) and progressive supranuclear palsy (PSP).

Tau aggregation inhibitor

Growing community of inventors

Kyoto, Japan

Yuki Shinzaki