Mie University

Takara Bio Inc.

Yuki Orito

Akihiro Morita

Haruhiko Isawa

Masao Yuda

Yasuo Chinzei

Junichi Mineno

Hiroshi Shiku

Sachiko Okamoto

Yasunori Amaishi

Provided are a chimeric antigen receptor comprising an extracellular domain capable of binding to an antigen, a transmembrane domain and at least one intracellular domain, the chimeric antigen receptor being characterized in that an intracellular domain of a glucocorticoid-induced tumor necrosis factor receptor (GITR) is contained as the intracellular domain; a nucleic acid encoding the chimeric antigen receptor; a cell expressing the chimeric antigen receptor; and a method for producing the cell.

Chimeric antigen receptor

The present invention provides Ti-4 protein, which is a protein obtained from salivary gland of, and the present invention provides Ti-4 gene encoding the protein. As the Ti-4 protein exhibits inhibitory activity on platelet aggregation, a medicine comprising the Ti-4 protein as an active ingredient will serve as a platelet aggregation inhibitor possibly effective for prevention and treatment of myocardial infarction, pulmonary infarction and cerebral infarction. Moreover, the Ti-4 protein will also serve as a highly prospective lead compound in the development of novel platelet aggregation inhibitors.

Ti-4 protein derived from Triatoma infestans exhibiting activity to inhibit platelet aggregation

The present invention provides Ti-3 protein, which is a protein obtained from salivary gland of, and the present invention provides Ti-3 gene encoding the protein. As the Ti-3 protein exhibits inhibitory activity on platelet aggregation, a medicine comprising the Ti-3 protein as an active ingredient will serve as a platelet aggregation inhibitor possibly effective for prevention and treatment of myocardial infarction, pulmonary infarction and cerebral infarction. Moreover, the Ti-3 protein will also serve as a highly prospective lead compound in the development of novel platelet aggregation inhibitors.

Ti-3 protein derived from triatoma infestans exhibiting activity to inhibit platelet aggregation

Growing community of inventors

Suzuka, Japan

Yuki Orito