Eisai R&d Management Co., Ltd.

Japan Cash Machine Co., Ltd.

Yuki Ishihara

Nobuaki Sato

Yoshihiko Norimine

Kunitoshi Takeda

Yuichi Suzuki

Shinya Izawa

Koji Hagiwara

In a drum-type paper sheet accumulation device that sequentially supplies paper sheets to an outer circumferential surface of a payout drum, accumulates the paper sheets by winding the paper sheets in a stacked state, and returns the paper sheets all at once, a technique is provided which can keep a linear velocity of a paper sheet located at an outermost circumference of the payout drum constant and can maintain an arranged state of the paper sheets without any particular speed control. A paper sheet accumulation drumthat stacks and accumulates paper sheets supplied one by one on an outer circumferential surface thereof while rotating, includes a plurality of retractable membersthat are arranged on a paper sheet accumulation portion of the outer circumferential surface in a predetermined circumferential arrangement, are configured to be retractable between a most protruding position protruding radially outward and a retreat position retreating from the most protruding position radially inward, are each elastically biased in a protruding direction, and each come into contact with a paper sheet surface on an outer surface. The paper sheets are accumulated to spread over the retractable members.

Paper sheet accumulation drum, paper sheet accumulation device, and paper sheet processing device

A compound represented by formula (I), or a pharmaceutically acceptable salt thereof: wherein Rrepresents a group represented by the formula: a group represented by the formula: or a group represented by the formula: and Rrepresents a 3-methyltetrahydro-2H-pyran-4-yl group or 4-methoxycyclohexyl group.

Pyridinylpyrazoloquinoline compounds

A compound and/or pharmacologically acceptable salt thereof represented by the formula (I) has PDE9 inhibitory action, so that the intracerebral cGMP concentration is anticipated to be elevated. The PDE9 inhibitory action and the increase in cGMP lead to the improvement of learning and memory behaviors, and the compound (I) has a potential use of a therapeutic agent for cognitive dysfunctions in Alzheimer's disease. wherein Ris a hydrogen atom; Ris an aromatic ring group, etc.; Ris a hydrogen atom, etc; Ris a hydrogen atom; Ris an oxepanyl group, etc.; Ris a hydrogen atom.

Pyrazoloquinoline derivatives

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Tsukuba, Japan

Yuki Ishihara