Pfizer Corporation

Raqualia Pharma Inc.

Requalia Pharma Inc.

Yukari Matsumoto

Hiroki Koike

Yoshiyuki Okumura

Tatsuya Yamagishi

Kazunari Nakao

Sachiko Mihara

Yoshinobu Hashizume

Masako Hirota

Hiroshi Nakamura

Kana Kon-I

Hisoshi Nakamura

Kana Kon-i

This invention provides a compound of the formula (I): 

Substituted methyl aryl or heteroaryl amide compounds

This invention provides a compound of the formula (I): wherein

This invention provides the compounds of formula (I): or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof, wherein Rand Rindependently represent a hydrogen atom or the like; Rrepresents a hydrogen atom, or the like; Rrepresents a hydrogen atom or the like; represents one of the following or the like; Rrepresents an aryl group having from 6 to 10 ring atoms or the like; X represents an oxygen atom, or the like; Y represents an oxygen atom or the like and n represents an integer 0, 1 or 2. These compounds have ORL1-receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.

Alpha aryl or heteroaryl methyl beta piperidino propanamide compounds as ORL1-receptor antagonists

This invention provides the compounds of formula (I): or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof, wherein Rand Rindependently represent a hydrogen atom or the like; These compounds have ORL1-receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.

Alpha aryl or heteroaryl methyl beta piperidino propanoic acid compounds as ORL1-receptor antagonists

Growing community of inventors

Aichi-ken, Japan

Yukari Matsumoto