Nippon Zoki Pharmaceutical Co., Ltd.

Yukari Konishi

Takashi Ogino

Kunihiko Higashiura

Kazuhito Furukawa

A 2-phenylpiperazine derivative represented by the formula (I) or a pharmaceutically acceptable salt, hydrate, or complex thereof:wherein each of Xand Xis oxygen or two hydrogen atoms, XO, NH, NCH, or CH, n is an integer of 0 or 1, Ris hydrogen or lower alkyl and Ris hydrogen, cyano, tetrazolyl, aminotriazolyl , mesyl, t-butoxycarbonyl, or a lower alkyl which may be optionally substituted, Ris hydrogen, halogen, lower alkyl or lower alkoxy, each of Rand Ris hydrogen, lower alkoxy or trifluoromethyl, and a broken line indicates a single or double bond. The derivative may be used as a tachykinin antagonist in the treatment of diseases of the digestive system, nervous system and respiratory system, inflammation, allergy, carcinoid syndrome, chronic pain, headache, Crohn disease, depression and vomiting.

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Hyogo, Japan

Yukari Konishi