Sanwa Kagaku Kenkyusho Co., Ltd.

Yukari Kobara

Akira Tashita

Takahito Jomori

Takuji Kakigami

Fumio Takaiwa

Koichi Sugita

Hiroyasu Ebinuma

Yuji Hayashi

Saori Kasahara

Yoshiharu Tsubamoto

The present invention provides a method for highly producing a recombinant protein in a plant storage organ and a GLP-1 derivative. The plant storage organ in which the recombinant protein is highly produced is obtained by transformation with the use of a vector which comprises a recombinant protein gene, a cytokinin-related gene, a drug-resistant gene and a removable DNA element, in which the cytokinin-related gene and the drug-resistant gene exist in the positions so that they can behave together with the DNA element, while the recombinant protein to be expressed in the plant storage organ exists in the position so that it would not behave together with the DNA element. The GLP-1 is produced by using the method, and a derivative having been stabilized against enzymatic digestion is further provided.

GLP-1 derivative

The present invention provides a low-molecular inhibitor of GIP functions and, further, an agent for preventing/ameliorating obesity based on inhibition of GIP functions, which comprises, as an active ingredient, a compound represented by the following general formula (I): (wherein Rrepresents hydrogen, halogen, a nitro group or a cyano group, Rand Reach represent hydrogen or halogen, hydrogen or a methoxy group, or both Rand Rmay form an optionally substituted benzene or pyrrole ring, and A represents nitrogen or C&#x2014;Rwhereupon Rrepresents hydrogen, an optionally substituted C1 to C6 alkyl group, &#x2014;OR, &#x2014;NRR, &#x2014;NHCO&#x2014;Ror &#x2014;SO&#x2014;Ror may, together with R, form an optionally substituted benzene or pyrrole ring, R, Rand Reach represent hydrogen or an optionally substituted C1 to C6 alkyl group, Rrepresents a C1 to C6 alkyl group or the like, and Rrepresents an optionally substituted morpholyl group or the like) or a pharmaceutically acceptable salt thereof.

Agent for preventing/ameliorating obesity comprising methylidene hydrizide compound as active ingredient

Growing community of inventors

Nagoya, Japan

Yukari Kobara