Other

Nipro Corporation

Kawasumi Laboratories. Inc.

Taki Chemical Co., Ltd.

Yukari Imamura

Takao Okada

Noriaki Shirahama

Yoshimichi Fujiyama

Junzo Tanaka

Masanori Kikuchi

Makoto Sato

Kazuo Takakuda

Yoshihisa Koyama

Yohei Hoashi

Tomokazu Mukai

Tamaki Murayama

Kimihiro Miyamoto

Takatoshi Itoh

Shigeo Tanaka

Soichi Shono

Etsuro Yokoyama

Shunji Ichikawa

Shuji Suwa

Hisae Saito

Tatsuaki Miyaji

Noriaki Kawasumi Laboratories Inc Shirahama

Provided are an artificial dura mater having a laminated constitution of at least two layers of in vivo degradable polymers, at least one layer of them being a substrate layer, the substrate layer being formed of a lactic acid/glycolic acid/&#x3b5;-caprolactone copolymer, the copolymer having a component molar ratio of 60-85:3-15:10-30 mol % and the copolymer having an average chain length that satisfies the following expressions (1) to (3) and a process for the production thereof, and when this artificial dura mater is used, no liquid leakage is caused since the bloating of suture holes is small, and the period of time for which it retains its strength is suitably a little longer than the period of time required for the regeneration of an autodura mater,2&#x3c;()&#x3c;[%/(%+%+%)]&#xd7;&#xd7;0.058&#x2003;&#x2003;(1)1&#x3c;()&#x3c;[%/(%+%+%)]&#xd7;&#xd7;0.58&#x2003;&#x2003;(2)1&#x3c;()&#x3c;[%/(%+%+%)]&#xd7;&#xd7;0.58&#x2003;&#x2003;(3) wherein L(LA), L(GA) and L(CL) represent average chain lengths of lactic acid units, glycolic acid units and of caprolactone units, LA%, GA% and CL% represent molar ratios of a lactic acid component, a glycolic acid component caprolactone component in the copolymer and X is a polymerization degree of the copolymer.

Artificial dura mater and process for producing the same

A bioabsorbable release-sustaining pharmaceutical formulation using a biodegradable release-sustaining base material which can prevent an effective component drug from being released too rapidly just after administration of the formulation and then allow continued release of the drug for at least one month at a defined rate, is provided. For the biodegradable release-sustaining base material, a lactic acid-glycolic acid copolymer (PLGA) with an adjusted distribution in molecular weight is used.

Bioabsorbable pharmaceutical formulation

Biological materials

Growing community of inventors

Himeji, Japan

Yukari Imamura