Banyu Pharmaceutical Co. Ltd

Yukari Hirata

Satoru Ito

Toshifumi Kimura

Hiroshi Kawamoto

Hisashi Ohta

Atsushi Satoh

Gentaroh Suzuki

Akio Sato

Yasushi Nagatomi

The present invention provides the compounds represented by formula (I): (I) or pharmaceutical salts thereof, wherein: 

Diaryl-substituted five-membered heterocycle derivative

The present invention relates to a compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, wherein: Ris a linear or branched alkoxy group, a cycloalkoxy group, a linear or branched lower alkyl group, etc.; Ris halogen atom, a lower alkyl group, etc.; Qis carbon atom or nitrogen atom; Qis carbon atom which may be substituted with oxo group; the formula (III):&#x2003;&#x2003;(II)is a single bond or a double bond; A is a group selected from the group consisting of the substitutent group &#x3b1;; and Ris hydrogen atom, a lower alkyl group, cyano group, an alkoxy group or a trialkylsilyl group; having an mGluR1 inhibiting action and being useful as treatment and/or prevention of convulsion, acute pain, cerebral disturbance such as cerebral infarction or transient cerebral ischemia onset, anxiety, chemical dependency or Parkinson's disease.

Biaryl derivatives

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Tsukuba, Japan

Yukari Hirata