Panasonic Corporation

Panasonic Healthcare Co., Ltd.

Matsushita Electric Industrial Co., Ltd.

Panasonic Healthcare Holdings Co., Ltd.

Yukari Hataoka

Hiroaki Oka

Tetsuo Yukimasa

Hidenobu Yaku

Nobuhiko Ozaki

Maki Yotsuhashi

The object of the present invention is to provide a method for increasing an amount of Protein A to be immobilized on the self-assembled monolayer. Immobilizing Protein A to the self-assembled monolayer through the structure represented following formula (II) obviates the object. 

Method for immobilizing protein A on a self-assembled monolayer

Provided are a method for increasing an amount of glucose oxidase to be immobilized on the self-assembled monolayer and a sensor which comprises glucose oxidase immobilized with the method. The method of the disclosed technology is characterized by that one molecule of an amino acid is interposed between the self-assembled monolayer and the molecule of the glucose oxidase.

Method for immobilizing glucose oxidase on a self-assembled monolayer

Provided are a method for increasing an amount of streptavidin to be immobilized on the self-assembled monolayer and a sensor which comprises streptavidin immobilized with the method. The method of the current technology is characterized by that one molecule of an amino acid is interposed between the self-assembled monolayer and the molecule of streptavidin.

Method for immobilizing streptavidin on a self-assembled monolayer

The present invention provides an immunological assay suitable to be carried out on a chip. After an antigen-antibody complex in which an antigento be measured and an antibodyhave bound to each other was obtained in a reaction chamber, the amount of the antigen-antibody complex or the antibody that has not bound to the antigen to be measured by using a measurement solution obtained by using the sample solutionas a solvent. According to the present invention, the measurement solution for detecting the signal that reflects the amount of the substance to be measured can be obtained without using a buffer solution free from a substance to be measured, such as protein. Thus, it is not necessary to supply a buffer solution from the outside of the chip or to allow the buffer solution to be retained on the chip beforehand. Accordingly, an immunological assay can be carried out easily on a chip.

Immunological assay and chip

The present invention provides an immunological assay suitable to be carried out on a chip. After an antigen-antibody complex in which an antigen to be measured and an antibody have bound to each other was obtained in a reaction chamber, the reaction chamber is washed using a sample solution and thereby the antigen-antibody complex and the antibody that has not bound to the antigen to be measured are separated from each other. According to the present invention, the reaction chamber can be washed to an extent that allows a signal reflecting the amount of the antigen to be measured to be detected with accuracy comparable to the case of using a wash solution without using a wash solution that is typified by Tris-HCl buffer that does not contain any antigens to be measured such as protein. Thus, it is not necessary to supply a wash solution from the outside of the chip or to allow a wash solution to be retained on the chip beforehand. Accordingly, an immunological assay can be carried out easily on a chip.

A fluid chip has a liquid supportfor supporting a liquid, a fluid passageformed by being surrounded by the liquid supportand through which the liquidmoves, and a plurality of magnetic particlesdisposed in the fluid passage. The magnetic particlesare aggregated by a permanent magnetso as to block the fluid passageand thus cut off flow of the liquid. The magnetic particlesare dispersed along a part of a wall of the fluid passageso as to open the fluid passageand thus allow the liquidto flow.

Fluid chip, fluid movement control method using the same, and chemical reaction apparatus

A liquid delivery apparatushas a rotary substrate. The substrateformed with a fluid passageA for communicating a supply chamberA and target chamberA. An inlet end portionat which the fluid passageA is connected to the chamberA extends in a clockwise direction Rof rotational directions of the substrate. The inlet end portionholds a liquidin the chamberA by a capillary force. The rotation drive unitrotates the substrateso that an inertial force exceeding the capillary force and directed to the clockwise direction Racts on the liquidin the inlet end portion. Delivery behavior control of microfluid with a high degree of flexibility can be achieved.

Liquid delivery apparatus and liquid delivery method

The present invention provides a blood processing apparatus that can introduce a metered quantity of a blood sample into a chamber and does not require an opening linked to the chamber to be closed after the introduction of the blood sample. An introducing chamber, an injection port, and an air port are formed in a rotatable platform of a blood processing apparatus. The injection port links the introducing chamber with the outside of the rotatable platform. A blood sample is introduced from the injection port into the introducing chamber. A blood coagulant is held on the port wall surface of the air port and/or around a portion of the surface of the rotatable platform where the air port is open.

Growing community of inventors

Osaka, Japan

Yukari Hataoka