Nippon Kayaku Kabushiki Kaisha

Yuka Sugawara

Akira Shiozawa

Yuh-ichiro Ichikawa

Kenichi Matsubara

Takemitsu Nagahata

Hiroshi Akaba

Hideo Sugimura

Hiroo Hoshino

Kazuhisa Narita

Yukihiro Nishiyama

Jun-ichi Seki

Kouwa Yamashita

Sayuri Kato

A novel nucleic acid derivative represented by the following general formula (I) and physiologically acceptable salt thereof which are expected to have an antiviral activity: ##STR1## wherein B represents a nucleic acid base derivative; A.sup.1 and A.sup.2 represent, independently of each other, OR.sup.1 or OCOR.sup.1 ; R.sup.1 represents a hydrogen atom, a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group; l represents a number of 0 or 1; and m and n each represents an integer of 0-2; provided that when l and m are 0, n is 0 or 2.

Adenine and guanine derivatives for the treatment of hepatitis virus

This invention relates to cyclobutane derivatives represented by the following general formula (1) and physiologically acceptable salts thereof: ##STR1## wherein B represents a nucleic acid base derivative, R.sup.1 and R.sup.2 independently represent hydrogen atom, dialkylaminoacyl group, 1,4-dihydro-1-methylnicotinoyl group or substituted phosphoric acid group, provided that either one of R.sup.1 and R.sup.2 is a group other than hydrogen atom. The compounds of this invention exhibit a high oral absorbability and are metabolized in vivo into the compounds of formula (1a). Accordingly, the compounds of this invention are expectedly useful as antiviral agent.

Phenoxyphosphoryloxymethyl cyclobutyl purines

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Kawaguchi, Japan

Yuka Sugawara