Sanwa Kagaku Kenkyusho Co., Ltd.

Ube Industries, Inc.

Yuka Kuno

Yasuhito Yamamoto

Yasunori Tsuzaki

Hiroki Nagano

Ryo Iwamura

Akira Takama

Mitsuaki Takeuchi

Hiroyuki Setoguchi

Toshiyuki Miyazawa

Daisuke Kurumazuka

Satoko Harada

Toru Izuchi

Morio Okabe

Hiroto Akaza

Yurie Yamada

Yukiyasu Asano

Izumi Gotoh

Nobuyoshi Kasugai

Naoki Takahashi

Keita Sakai

Hiroki Fujieda

Yasushi Ohsawa

Hiroyo Kataoka

Katsunori Kitamoto

Disclosed herein are a crystal comprising a compound, which has &#x3bc;-opioid receptor antagonistic action, few side effects, and high safety, and having high purity and excellent physical properties (stability, solubility, etc.), and a method for producing the crystal. The crystal is a crystal of a salt comprising: a compound represented by a formula (I) [wherein Ris a hydrogen atom or a halogen atom, and Ris a group selected from the group consisting of and an acid selected from the group consisting of hydrochloric acid, hydrobromic acid, and oxalic acid, or a hydrate thereof.

Crystal of salt of novel 3-azabicyclo[3.1.0]hexane derivative and pharmaceutical use thereof

A compound having a V2 receptor agonistic activity is provided. Providing a pharmaceutical composition which contains, as an active ingredient, a compound represented by general formula (I) described below: [Ris formula described below: (A is a lower alkylene group which may be substituted with lower alkyl group; Ris a hydrogen atom; Ris a hydroxyl group, an aromatic heterocyclic group which may be substituted with lower alkyl group, carbamoyl group); Ris a hydrogen atom or lower alkyl group; Ris lower alkyl group which may be substituted with 1-3 fluorine atoms, or halogen atom; Ris a five-membered aromatic monocyclic heterocyclic group, five-membered non-aromatic monocyclic heterocyclic group, (provided each heterocyclic groups contain at least one nitrogen atom and may be substituted with a lower alkyl group); and Ris a lower alkyl group, halogen atom], or pharmacologically acceptable salt thereof.

Benzoazepine derivative and medical use thereof

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Nagoya, Japan

Yuka Kuno