Shimadzu Corporation

Kobe University

Kyushu University

Miyazaki Prefecture

Yuka Fujito

Tomohisa Hasunuma

Takanari Hattori

Logan Miller

Takeshi Bamba

Tairo Ogura

Michio Butsugan

Keita Sakurai

Miho Sakai

Risa Ishii

Kenichiro Tanaka

An analysis method includes: performing liquid chromatography using a mobile phase including an adsorption prevention agent for preventing adsorption of a sample including a compound having a phosphate group to metal; and performing mass spectrometry on an eluate of the liquid chromatography. The adsorption prevention agent includes an oxalic acid or a salt of the oxalic acid.

Analysis method, adsorption prevention agent, and analysis kit

A liquid chromatograph includes at least one mobile phase supply flow path (), at least one cleaning solution supply flow path () joining the mobile phase supply flow path (), an analysis flow path () provided with a separation column (), a sampling flow path () provided, at a tip end thereof, with a sampling needle (), a switcher () including a high-pressure valve () having an injection port () and configured to switch a flow path configuration of the liquid chromatograph between a loading state in which the analysis mobile phase supply flow path () and the analysis flow path () are connected in a fluid manner without the sampling flow path () and an injecting state in which the sampling flow path () is interposed between the analysis mobile phase supply flow path () and the analysis flow path () when a tip end of the needle () is inserted into the injection port (), and a controller () configured to execute, when a predetermined condition is satisfied, the cleaning operation of supplying the mobile phase and the cleaning solution to the analysis flow path () and/or the sampling flow path () to temporally change the composition of liquid flowing in the analysis flow path () and/or the sampling flow path ().

Liquid chromatograph and flow path cleaning method in liquid chromatograph

As a technique for separating odorous compounds by using a supercritical fluid chromatograph, a method for separating an odorous compound is provided which includes a process of carrying a sample containing an odorous compound into a column filled with a packing material made of a polymer having an unsaturated hydrocarbon structure, by a flow of a mobile phase which is a supercritical fluid of a predetermined substance.

Method for separating odorous compound and supercritical fluid chromatograph

A supercritical fluid chromatograph includes a liquid sender that supplies a mobile phase including a supercritical fluid to a supply flow path, first and second back pressure regulators that are respectively provided in first and second flow paths into which a path from the liquid sender branches and an analysis column provided at a position farther upstream than the first back pressure regulator in the first flow path. An analysis assistance device includes a storage a receiver, a first calculator, and a presenter.

Analysis assistance device, analysis assistance method, non-transitory computer readable medium storing analysis assistance program and analysis system

A controller of a liquid chromatograph is configured to execute, as an analysis operation in an analysis unit, a sample injection step of bringing a high-pressure valve into a loading state, sucking a sample from a tip of a needle to hold a sample in a sampling channel, then connecting the sampling channel to an injection port and bringing the high-pressure valve into an injecting state, and supplying a mobile phase from a liquid supplier, thereby injecting a sample held in the sampling channel into an analysis channel, and an analysis step of separating components of a sample injected into the analysis channel in a separation column by bringing the high-pressure valve in the loading state and supplying the mobile phase from the liquid supplier after the sample injection step is ended. The controller is configured to execute, as the analysis operation, a system cleaning step of cleaning a liquid flowing route.

Liquid chromatograph and analysis method using liquid chromatograph

A column packing material for supercritical fluid chromatography which allows good peak shape to be obtained in the analysis of free fatty acids, etc. and in the analysis of agricultural chemicals, etc., and has excellent durability for repeated analysis. The column packing material for supercritical fluid chromatography includes polymer particles containing cross-linked polymer, the degree of swelling of which after absorbing tetrahydrofuran and the degree of swelling of which after absorbing methanol are both 1.4 or less.

Column packing material for supercritical fluid chromatography, column for supercritical fluid chromatography and preparation method therefor

An analysis assistance method includes setting pressure in a first BPR to a value higher than a prescribed second set value with pressure in a second BPR set to a second set value, instructing a supercritical fluid chromatograph to supply a mobile phase to a supply flow path at a flow rate of the mobile phase that is to be theoretically supplied to a first flow path when the mobile phase is supplied to the supply flow path at a prescribed total flow rate and a prescribed sample introduction ratio, and gradually decreasing a set value of the pressure in the first BPR, and detecting a set value of the pressure in the first BPR at the time when supply of the mobile phase to a second flow path is stopped due to a decrease in set value of the pressure in the first BPR, as a first set value.

Analysis assistance method, analysis assistance device, non-transitory computer readable medium and analysis system

A supercritical fluid device includes an analytical channel, a liquid delivery part for delivering a mobile phase constituting a supercritical fluid in the analytical channel, a back pressure regulator for controlling a pressure of the analytical channel so as to cause the mobile phase in the analytical channel to reach a supercritical state, a sample injecting device that includes a sample holder for holding a sample and a switching valve for switching between a state where the sample holder is arranged on the analytical channel and a state where the sample holder is not arranged on the analytical channel, a bypass channel whose one end is connected to a position upstream of the sample injecting device and whose other end is connected to a position downstream of the sample injecting device on the analytical channel, and an analytical column for separating a sample introduced by the sample injecting device into individual components, the analytical column is provided downstream of the position to which the other end of the bypass channel is connected on the analytical channel.

Supercritical fluid device

A mass spectrometer for performing a selected ion monitoring (SIM) measurement and/or multiple reaction monitoring (MRM) measurement on each of one or a plurality of target components contained in a sample under one or a plurality of measurement conditions is provided. The mass spectrometer includes: a storage sectionin which SIM measurement conditions and/or MRM measurement conditions are previously stored for a plurality of components; a measurement condition selection receiverfor performing the following operations when a command to create a method file in which measurement conditions are described is issued by a user: reading the selected ion monitoring measurement conditions and/or multiple reaction monitoring measurement conditions of the plurality of components, displaying the measurement conditions on a screen, and receiving a selection by the user; and a method file creatorfor creating a method file in which a measurement condition selected by the user is described.

Mass spectrometer

A chromatograph mass spectrometer for performing SIM measurement and/or MRM measurement on a plurality of target components includes: a memoryfor previously storing measurement conditions created for each of the target components, the measurement conditions including an SIM measurement ion or an MRM transition, a measurement execution time period, and an initial dwell time; a measurement time dividerfor dividing an entire measurement time into a plurality of partial time periods having different combinations of measurements executed in the same time period; a time period input receiverfor receiving an input for selecting one of the partial time periods; a sensitivity information input receiverfor receiving an input of sensitivity information relating to the measurement conditions executed in the selected partial time period; a dwell time calculatorfor calculating a changed dwell time by increasing or reducing the initial dwell time according to details of the input of the sensitivity information; and a loop time calculatorfor calculating a loop time from the changed dwell time and outputting the calculated loop time.

Growing community of inventors

Kyoto, Japan

Yuka Fujito