Columbia University

Yuk Kee Cheung Poh

Samuel K Sia

Sau Yin Chin

Anne-Celine Kohler

Keith Yeager

Curtis D Chin

Robert Houghtaling

Tassaneewan Laksanasopin

Olga Ordeig

Mario Matteo Modena

Paolo Cadinu

MicroElectroMechanical System (MEMS) devices can be fabricated completely of hydrogel materials. Such hydrogels can include polyethylene glycol with diacrylate functional groups (e.g., PEGDA), which are photopolymerizable in the presence of crosslinkers and photoinitiators. By using PEGDA monomers of different molecular weights and at different percentages, the mechanical properties of the polymerized gels and their respective permeabilities can be tuned. This spatial variation in properties and permeabilities can lead to different functionalities between different portions of the hydrogel MEMS device. Portions of the hydrogel device may be remotely actuated by applying wave energy, for example, a magnetic field, high intensity focused ultrasound, and/or infrared radiation. The remote actuation can allow the device to be actuated in vivo, for example, to allow the device to deliver a drug or other substance at a desired time and/or desired location within a patient.

Systems, methods, and devices for in vivo delivery using remote actuation of implantable hydrogel MEMS devices

A portable unitary device handheld diagnostic device can be operated with minimal power requirement and provides ease of operation as well as low cost communication of diagnostic data from remote locations. The device can provide nucleic-acid based diagnostics with minimal training, little to no sample preparation, and generates diagnostic data in about 45 minutes. A system can enable point of care transmission from any location globally using a low cost satellite-based data link technique, for example, Short Burst Data (SBD), combined with data encoding.

Field optimized assay devices, methods, and systems

Growing community of inventors

Cambridge, MA, United States of America

Yuk Kee Cheung Poh