Nektar Therapeutics

Yujun Wang

Mary J Bossard

Xiaofeng Liu

Cherie F Ali

Deborah H Charych

Haim Moskowitz

Steven O Roczniak

Ping Zhang

C Simone Jude-Fishburn

Harold Zappe

Dennis G Fry

Dawei Sheng

Christine Taylor Brew

Jicai Huang

Elizabeth Louise Minamitani

Christine Brew

Elizabeth Minamitani

Conjugates of an interleukin-2 ('IL-2') moiety and one or more nonpeptidic, water-soluble polymers are provided. Typically, the non-peptidic, water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, methods of administering compositions to an individual, nucleic acid sequences, expression systems, host cells, and methods for preparing IL-moieties.

Conjugates of an IL-2 moiety and a polymer

Method of refolding an interleukin-2 (IL-2) protein

Conjugates of an interleukin-2 ('IL-2') moiety and one or more nonpeptidic, water-soluble polymers are provided. Typically, the nonpeptidic, water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, methods of administering compositions to an individual, nucleic acid sequences, expression systems, host cells, and methods for preparing IL-moieties.

The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.

Polymer conjugates of protegrin peptides

Polymer conjugates of therapeutic peptides

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Fremont, CA, United States of America

Yujun Wang