Toa Eiyo Ltd.

Yujiro Uchino

Hidekazu Masaki

Masayuki Kageyama

Koichi Takayanagi

Hiroshi Takasugi

Yoichi Iwasaki

Tomoyuki Nagayama

Ryutaro Shimono

Provided is a compound which is useful as a prophylactic or therapeutic agent for various diseases in which T-type calcium channels are involved, such as hypertension, arrhythmia, pain and cancers, the compound having antagonistic activity against T-type calcium channels, being highly stable in the body and having low risk of, for example, genotoxicity. Disclosed is a compound represented by the following general formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof: 

Substituted tropane derivatives

Provided is a novel compound which shows an antagonistic effect against T-type calcium channels, and is useful as a pharmaceutical product. A compound represented by general formula (I), and a pharmaceutical agent containing the same, are disclosed: wherein n represents the number of nitrogen atoms contained in the 6-membered fused aromatic ring, and is 0, 1 or 2; p represents the number of nitrogen atoms contained in the 6-membered aromatic ring, and is 0 or 1; X represents an oxygen atom, &#x2014;SO&#x2014; or &#x2014;N(R)&#x2014;; and Rto Reach represents a hydrogen atom or other substituents.

Fused imidazole derivative

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Saitama, Japan

Yujiro Uchino