Sumitomo Chemical Company, Limited

Shionogi Company Limited

Sumitomo Chem.co., Ltd.

Yujiro Kiyoshima

Akihiko Nakamura

Katuhisa Masumoto

Mikio Sasaki

Hiroyuki Kai

Moriyasu Masui

Akira Takase

Yoji Sakito

Kazuya Minamisaka

Mamoru Shirahata

Atukazu Iwata

Yasunobu Miyamoto

Asako Tanahashi

There is disclosed a process for producing hexahydro-2-oxo-1H-thieno&lsqb;3,4-d&rsqb;imidazole-4-pentanoic acid of the formula (2):

Method for producing hexahydro-2-OXO-1H-thieno&lsqb;3,4-D&rsqb;imidazole-4-pentanoic acid

A method for purifying O,S-dimethyl N-acetyphosphoramidothioate, which is characterized by subjecting a crude crystal of O,S-dimethyl N-acetylphosphoramidothioate to recrystallization by using a two-phase solvent system comprising water and an organic which is an aromatic hydrocarbon, an aliphatic carboxylic acid ester or aliphatic ketone, wherein the amount of water is 0.1 to 2 parts by weight and the amount of the organic solvent is 1 to 20 parts by weight to 1 part by weight of the crude O,S-dimethyl N-acetylphosphoramidothioate. A further method for purifying O,S-dimethyl N-acetylphosphoramidothioate, which is characterized by extracting O,S-dimethyl N-acetylphosphoramidothioate from an aqueous solution of crude O,S-dimethyl N-acetylphosphoramidothioate with an organic solvent which is a carbonate ester, an aliphatic carboxylic acid ester, an aliphatic ketone, an aliphatic alcohol or a mixture of two or more thereof, wherein the solubility of water in the organic solvent is in a range of from 1 to 20% by weight, and crystallizing O,S-dimethyl N-acetylphosphoramidothioate from the resulting organic phase.

Method for purifying O, S-dimethyl N-acetylphosphoramidothioate

Process for producing .alpha.-hydroxyiminophenylacetonitriles

Method for purifying O,S-dimethyl N-acetylphosphoramidothioate

Process for producing carboxylic acid derivatives

There is disclosed a process of producing an N-alkylacetamide of the general formula (III): ##STR1## wherein X.sup.1, X.sup.2 and X.sup.3 are the same or different and are independently hydrogen, lower alkyl, lower alkoxy, lower alkenyl, halogen or trifluoromethyl; R.sup.1 and R.sup.2 are the same or different and are independently lower alkyl; and  represents a chemical bond of E- or Z-configuration, or a mixture of these configurations, which includes the steps of:

Process of producing N-alkylacetamides

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Oita, Japan

Yujiro Kiyoshima