Sumitomo Chemical Company, Limited

Ge Yokogawa Medical Systems, Limited

Riken Corporation

Nippon Kayaku Kabushiki Kaisha

Ono Pharmaceutical Co., Ltd.

Tokyo University of Science, Center for Science and Technology Exchange

Yujiro Hayashi

Kazuhiko Hayakawa

Hiroyuki Osada

Masaaki Sakuma

Katsumasa Nose

Hideaki Kakeya

Hayato Ishikawa

Kazuhiko Sato

Osamu Furuta

Mitsuru Shoji

Koichi Narasaka

Zenchi Hiyama

Disclosed are a process suited to large scale synthesis with high yield for producing oseltamivir phosphate, in which a preparation of oseltamivir phosphate which is highly safe as a pharmaceutical product can be produced, and an intermediate compound for producing oseltamivir phosphate. In this production process, an intermediate compound represented by general formula (V) is synthesized by employing Michael reaction/Michael reaction/Horner-Wadsworth-Emmons reaction, and oseltamivir phosphate is produced by converting the substituent groups in this intermediate compound. 

Process for producing oseltamivir phosphate and intermediate compound

The invention relates to a method of producing optically active &#x3b2;-aminoaldehyde compound (3) by reacting imine compound (1-1) or sulfone compound (1-2) with aldehyde compound (2) in the presence of an optically active pyrrolidine compound. wherein each symbol is as defined in the specification.

Process for producing optically active &#x3b2;-amino aldehyde compound

The invention relates to a method of producing optically active 4-chloro-3-hydroxybutanal compound (2) by reacting chloroacetaldehyde with aldehyde compound (1) in the presence of optically active pyrrolidine compound (5). wherein each symbol is as defined in the specification.

Process for producing optically active 4-chloro-3-hydroxybutanal compound

The present invention provides a production method of optically active 3-substituted-3-formyl-2-hydroxypropanoic acid compound (4), which includes a step of reacting glyoxylic acid compound (1-1) or (1-2) with aldehyde (2) in the presence of optically active pyrrolidine compound (3); wherein each symbol is as defined in the specification.

Process for producing optically active 3-substituted-3-formyl-2-hydroxypropanoic acid compound

The present invention provides a method that allows production of stereospecific and asymmetrical five-membered ring-containing compounds serving as synthetic intermediates for formation of five-membered rings of prostaglandins and the like, with high yield and excellent stereoselectivity in terms of diastereoselectivity and enantioselectivity in a short process without requiring troublesome procedures such as optical resolution. The method for producing a five-membered ring-containing compound includes a cyclization step of condensing and cyclizing an &#x3b1;,&#x3b2;-unsaturated nitro compound represented by the following chemical formula (I) with a 1,4-butanedione compound, in the presence of a catalyst formed by a compound having a pyrrolidine ring and an optically active &#x3b1;-carbon relative to the nitrogen on the ring, in a water-insoluble organic solvent and/or a non-oxygen atom-containing water-soluble organic solvent so as to produce the five-membered ring-containing compound represented by the following chemical formula (II).  

Method for producing five-membered ring-containing compound

A compound represented by the general formula (I): (I) wherein R represents linear, branched, or cyclic alkyl or aryl; a process for producing the compound; and an antitumor agent containing the compound as an active ingredient.

Compound having antitumor activity and process for producing the same

A compound represented by the general formula (I): (I) wherein R represents linear, branched, or cyclic alkyl or aryl; a process for producing the compound; and an antitumor agent containing the compound as an active ingredient. 

The corresponding &#x3b1;-aminooxy ketone is manufactured with a high yield and a high enantioselectivity. A manufacturing method for an optically active &#x3b1;-aminooxy ketone derivative expressed by formula (1), wherein a ketone expressed by formula (2) is caused to react with a nitroso compound expressed by formula (3) in the presence of a proline derivative expressed by formula (4). In the formula, Rand Rrespectively denote an alkyl, alkenyl or alkynyl group, and Rand Rmay be linked to form a ring. Rdenotes an aryl, heterocyclic, alkyl, alkenyl or alkynyl group. A denotes a hydrogen atom, alkoxy group, aryloxy group, acyloxy group or silyloxy group which may have a substituent.

Optically active &#x3b1;-aminooxyketone derivatives and process for production thereof

In order to give a physician easy access to a patient placed in an interjacent space within a vertical magnet apparatus of a vertical magnet-type MRI apparatus, support and movement mechanisms are provided on respective opposing surface sides of a pair of vertical opposing magnets for supporting a cradle or a seat of a chair on belts and moving the cradle or the seat in the horizontal direction by motors and in the vertical direction by hydraulic cylinders

MRI vertical magnet apparatus and MRI apparatus

The present invention is directed to joint motion imaging and provides a vertical magnet type MRI system comprising a vertical magnet unit ( ) having a pair of opposite vertical magnets ( ), a movable table ( ) provided with wheels ( ) for traveling and a cradle ( ) to carry a specimen laid down thereon, and capable of being moved into and moved out of a space between the pair of opposite vertical magnets ( ), table locking devices ( ) for locking the movable table ( ) with the cradle ( ) being in place between the pair of opposite vertical magnets ( ), a movable chair ( ) provided with wheels ( ) for traveling and capable of being moved into and moved out of the space between the pair of opposite vertical magnets ( ), and a chair locking device ( ) for locking the movable chair ( ) in place between the pair of opposite vertical magnets ( ).

Diagnostic system with a chair and table movable on rails provided on vertical magnets thereof

In order not to nip the clothes or skin of a subject between the joining portions of coil members when a detecting coil for a magnetic resonance diagnostic apparatus is fitted around a region of the subject such as the leg or neck, the detecting coil 100 for a magnetic resonance diagnostic apparatus, which can be separated into an upper coil member 10 and a lower coil member 20 and has an annular shape when these members 10, 20 are integrally joined, is provided at the joining portions of the lower coil member 20 with guards 27, 28 of a silicone rubber having a hardness of Hs80.

Detecting coil for magnetic resonance diagnostic apparatus

An RF coil is surrounded externally with dampers. Arresting plates are attached securely to the exterior of the dampers to arrest vibrations of the latter. The thickness of the arresting plates is made substantially the same as that of a body coil bobbin.

Body coil, gradient coil and NMR apparatus

Cyclobutane derivatives represented by the following general formula (I): ##STR1## wherein X represents a group represented by the formula ##STR2## or the formula ##STR3## which is expected to be useful as reagents, drugs, agricultural chemicals and perfumes as well as an intermediate for the preparation thereof.

Growing community of inventors

Tokyo, Japan

Yujiro Hayashi