Chinese Academy of Sciences

China Resources Powtech (shanghai) Co., Ltd.

Yujie Wang

Lei Zhang

Jia Tao Li

Yong You

Lei Feng

Yu Cheng

Jin Li

Yubo Zhou

Xiaohua Chen

Guocheng Li

Xiaobei Hu

Jianmin Li

Weijuan Kan

Bingyin Luo

Jia Li

Gaoya Xu

Yuhua Zhong

Binshan Zhou

Kenian Yan

Tian Mi

Hongtao Tian

Huijun Nie

Huiyuang Ren

Linhai Xu

Andi Guo

The present invention relates to a polysubstituted isoindoline compound as shown in general formula (I), and a preparation method, a pharmaceutical composition and the use thereof. In particular, the polysubstituted isoindoline compound is provided in the present invention as a class of novel CRL4E3 ubiquitin ligase modulators in structure, wherein same has a stronger antitumor activity and antitumor spectrum, and can be used to prepare drugs for treating CRL4E3 ligase-related diseases.

Isoindoline compound, preparation method, pharmaceutical composition and use thereof

A system and method for detecting voltage of a battery pack. The system comprises a level transfer circuit array, a multipath data selector, a decoder, a trimming calibration circuit, and an output buffer. The decoder is configured to parse a battery pack cell gating signal; the level transfer circuit array is configured to convert a gated battery pack cell voltage into a common grounded voltage; the multipath data selector is configured to transmit the common grounded voltage, which is converted by the level transfer circuit array, of a battery pack cell to the trimming calibration circuit; the trimming calibration circuit is configured to correct the received common grounded voltage of the battery pack cell; and the output buffer is configured to buffer the common grounded voltage, which is trimmed and calibrated by the trimming calibration circuit, of the battery pack cell.

System and method for detecting voltage of battery pack

Growing community of inventors

Shanghai, China

Yujie Wang