Cspc Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.

Shijiazhuang Pharmaceutical Group Ouyl Pharma. Co., Ltd.

Cspc Zhongqi Pharmaceutical Technology Co., Ltd.

Yujie Chen

Ying Shi

Yi Mi

Hanyu Yang

Yuxiu Ma

Qingzhi Gao

Xiaozhuo Chen

Dongmin Shen

Guorui Mi

Yaran Zhang

Yang Guo

Linjing Fan

Chunlei Liu

Xuejiao Zhang

Min Bai

Xuliang Wang

Nanping Zhong

Xianfeng Zhao

Hui Ma

Denghuang Gong

Provided are a quinazoline derivative, a pharmaceutical composition containing the same, a method for preparation of said derivative, and an application of same as an anti-cancer drug. 

Quinazoline derivative

The present invention relates to a benzamide derivative of general formula I, a drug composition containing same and a use thereof as a drug, wherein the definitions of R, Z and Q are as described in the description. 

Benzamide derivative

The present invention relates to the preparation of the (S)-(&#x2212;)-amlodipine and (R)-(+)-amlodipine by means of enantiomeric separation of racemic amlodipine mixture, in which, L- or D-tartaric acid is used as resolution agent, and organic solvent containing 2-butanone is used as solvent. The 2-butanone used in the present invention has the advantage of low boiling point, low toxicity, litter pollution, and the method is suitable for large-scaled production.

Method for the enantiomoeric separation of optical active amlodipine

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Shijiazhuang, China

Yujie Chen