Fujifilm Corporation

Yuji Yoshimitsu

Daisuke Nakagawa

Makoto Takahashi

Yosuke Yamamoto

Kazuhei Kaneko

Mika Imamura

Motomasa Takahashi

Hirotaka Satou

Hidenobu Kuniyoshi

Takuya Matsumoto

Hirofumi Omura

Keita Tanaka

Takashi Tamura

Masaaki Inoue

Takayoshi Watanabe

Takahiro Hohsaka

Provided are a method for producing a peptide compound including a step of using a condensed polycyclic aromatic hydrocarbon compound represented by Formula (1); a protective group-forming reagent including the compound; and the compound. In Formula (1), a ring A represents a condensed polycyclic aromatic hydrocarbon ring, Y's each independently represent —CHOH, —CHNHR, —CHSH, or —CHX, where R represents a hydrogen atom, an alkyl group, or an aralkyl group, and Xrepresents Cl, Br, or I, k represents an integer of 1 to 5, n represents 1 or 2, and R's each independently represent an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group.

Method for producing peptide compound, protective group-forming reagent, and condensed polycyclic aromatic hydrocarbon compound

Provided are a method for producing a peptide compound including a step of using an aromatic heterocyclic compound represented by Formula (1); a protective group-forming reagent including the compound; and the compound. In Formula (1), a ring A represents an aromatic heterocyclic ring, Y's each independently represent —OH, —NHR, —SH, or —X, where Xrepresents Cl, Br, or I, Rand Reach independently represent an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, Rs' each independently represent a monovalent aliphatic hydrocarbon group, a (1+c)-valent aromatic group, or a (1+c)-valent heteroaromatic group, where, in a case where both a and c is 0, Ris a monovalent aliphatic hydrocarbon group, and the number of carbon atoms in at least one aliphatic hydrocarbon group of R, R, or Ris 12 or more

Method for producing peptide compound, protective group-forming reagent, and aromatic heterocyclic compound

An object of the present invention is to provide a novel cyclic peptide compound excellent in cell membrane permeability, a method for producing the same, a composition for screening use, and a method for selecting a cyclic peptide compound that binds to a target substance. According to the present invention, a peptide compound represented by Formula (1) or a salt thereof is provided. In the formula, the symbols have the meanings as defined in the specification of the present application. 

Peptide compound and method for producing same, composition for screening use, and method for selecting peptide compound

Disclosed are a compound and a pharmaceutical composition that exhibit an excellent drug efficacy against a tumor, in particular a tumor which has acquired resistance to gemcitabine. Specifically, provided is a thionucleoside derivative represented by General (in the formula, Rrepresents a hydroxyl group which may be protected, a Calkoxy group which may be substituted, or the like; Rrepresents a Calkoxy group which may be substituted, a Ccycloalkoxy group which may be substituted, or the like; and Rrepresents a hydrogen atom or the like); or a salt thereof. Further, provided is a pharmaceutical composition containing such a thionucleoside derivative or a salt thereof.

Thionucleoside derivative or salt thereof, and pharmaceutical composition

Disclosed are a compound and a pharmaceutical composition that exhibit an excellent drug efficacy against a tumor, in particular a tumor which has acquired resistance to gemcitabine. Specifically, provided is a thionucleoside derivative represented by General Formula [1] 

Growing community of inventors

Ashigarakami-gun, Japan

Yuji Yoshimitsu