Nof Corporation

Nec Lcd Technologies, Ltd.

Nec Corporation

Japan Synthetic Rubber Co., Ltd.

Central Glass Company, Limited

Honda Motor Co., Ltd.

Tokyo Institute of Technology

Kabushiki Kaisha Toshiba

Honda Giken Kogyo Kabushiki Kaisha

Massachusetts Institute of Technology

Tdk Corporation

Nippon Steel Corporation

Seiko Instruments Inc

Asahi Glass Company, Limited

Keihin Corporation

Yuji Yamamoto

Michiaki Sakamoto

Mamoru Okamoto

Shinichi Nakata

Hironori Kikkawa

Hiroaki Matsuyama

Muneo Maruyama

Masayoshi Suzuki

Teruaki Suzuki

Yoshihiko Hirai

Hiroki Yoshioka

Toshiya Ishii

Seiji Suzuki

Takahiko Watanabe

Kiyomi Kawada

Takuma Tsubusaki

Ken Sumiyoshi

Hiroshi Kanoh

Takayuki Ishino

Chika Itoh

Hirofumi Ihara

Ken-ichiro Nakamoto

Kenji Sakanoue

Tohru Yasukohchi

Ken-Ichi Takatori

Syunsuke Ohashi

Masami Yamashita

Yusuke Tsuda

Midori Hirai

Shusuke Akazaki

Takashi Kurata

Kazuyoshi Nakazawa

Fumiaki Manabe

Nobuhiro Nishiyama

Junichiro Watanabe

Akitsugu Kurita

Makoto Matsumoto

Yuichi Funahashi

Tateki Furuyama

Hiroyasu Takemoto

Masaki Kamiya

Makoto Matsui

Masanobu Hidehira

Takahiro Nomoto

Keishiro Tomoda

Hisao Nagai

Yoshio Mohri

Yoshinobu Suzuki

Yoshitaka Horie

Takashi Hiroishi

Hiroshi Sakamoto

Takayuki Yamada

Masahiro Tsuchiya

Kenji Arai

Shigeru Kimura

Elazer Reuven Edelman

Yutaka Saitoh

Hiroyuki Sugiura

Hiroshi Muramatsu

Yoichi Ando

Kazumi Kobayashi

Yasuyoshi Hidaka

Yuriko Kaida

Masatsugu Shigeno

Naoya Watanabe

Yoshiharu Shirakawabe

Eriko Fujimaki

Hidehisa Nanai

Takahide Mizuno

Kensuke Makita

Toshio Teramoto

Jun Ishikawa

Akira Inoue

Yasuto Higashida

Kazuyoshi Miyajima

Kentaro Onuma

Gaku Sato

Natalie Artzi

Toshitaka Hachiro

Yutaka Tsuji

Seiichi Atomori

Mitsuo Hashizume

Tsuyoshi Takehana

Tomohiko Hasegawa

Shigeaki Esaka

Shouichi Kuroha

Yoshihiro Moroi

Tatsuya Miyai

Mika Tahara

Osamu Matsuzawa

Kazuhiko Yamamoto

Yasunori Arai

Satoshi Furuhashi

Amiko Nihei

Masaki Ota

Kazuma Akimoto

Satoshi Matsuo

Ryohei Koguchi

Makoto Harada

Minoru Ozaku

The invention provides a bio-related substance bonded to a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The bio-related substance bonded to a degradable polyethylene glycol derivative is represented by the formula (A): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, D is the bio-related substance, L1, L2, L3, L4 and L5 are each independently a single bond or a divalent spacer, and y is 1-40.

Degradable polyethylene glycol conjugate

The invention provides a high-molecular-weight polyethylene glycol derivative that does not cause vacuolation of cells. The degradable polyethylene glycol derivative is represented by the following formula (1): wherein m is 1-7, n1 and n2 are each independently 45-682, p is 1-4, R is an alkyl group having 1-4 carbon atoms, Z is an oligopeptide with 2-8 residues composed of neutral amino acids excluding cysteine, Q is a residue of a compound having 2-5 active hydrogens, X is a functional group capable of reacting with a bio-related substance, and L, L, L, Land Lare each independently a single bond or a divalent spacer.

Degradable polyethylene glycol derivative

A biodegradable polyethylene glycol derivative in which a polyethylene glycol chain is linked by an acetal linker capable of accurately controlling the hydrolysis rate under different pH environments in the living body, and whose division rate into a polyethylene glycol chain of low molecular weight in the living body can be accurately controlled. The biodegradable polyethylene glycol derivative is represented by formula (1) or formula (2) as described.

Biodegradable polyethylene glycol derivative having cyclic benzylidene acetal linker

A hydrophilic polymer derivative having a cyclic benzylidene acetal linker represented by the following formula (1): wherein Rand Rare each independently a hydrogen atom or a hydrocarbon group; R, R, Rand Rare each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; Xis a chemically reactive functional group; P is a hydrophilic polymer; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; w is an integer of 1 to 8; and Zand Zare each independently a selected divalent spacer.

Hydrophilic polymer derivative having cyclic benzylidene acetal linker

A piercer plug with increased life and a method of manufacturing it are provided. The piercer plugincludes a tip portionand a trunk portionmade of the same material as the tip portionand continuous to the tip portion. The trunk portionincludes a cylindrical portionhaving a hole used for attaching a bar. The tip portionis harder than the cylindrical portion

Piercer plug and method of manufacturing the same

A method of producing a polyoxyethylene derivative (1): where L1 is a divalent linker, X is a functional group capable of reacting with a physiologically active substance, a is 1 or 2, and n is from 11 to 3,650. The method includes Step (A): protecting 4 or 6 hydroxyl groups in a polyhydric alcohol having 5 or 7 hydroxyl groups by cyclic benzylidene acetalization to obtain a compound having a hydroxyl group at a 1-position and a protective group of a cyclic benzylidene acetal structure; Step (B): polymerizing from 11 to 3,650 moles of ethylene oxide to the compound obtained in the step (A) to obtain a polyoxyethylene derivative; Step (C): converting the hydroxyl group at a terminal of the polyoxyethylene derivative to a functional group capable of reacting with a physiologically active substance; and Step (D): deprotecting the protective group of the polyoxyethylene derivative.

Production method of polyoxyethylene derivative having plurality of hydroxyl groups at terminal

An energy management device comprises a first supply/demand information acquisition unit, a second supply/demand information acquisition unit, and a supply/demand management unit configured to determine, based on the first supply/demand information and the second supply/demand information, at least one of (i) an upper limit value of a power amount that the hydrogen generation system can receive from a power grid during a certain period, (ii) a target value of an amount of hydrogen that the hydrogen generation system generates during the certain period, (iii) an upper limit value of a power amount that each of the one or plurality of tri-generation systems can transmit to the power grid during the certain period, and (iv) a target value of a power amount that each of the one or plurality of tri-generation systems generates during the certain period.

Energy management device, hydrogen utilization system, non-transitory computer readable medium, and energy management method

An antibody-drug conjugate having a cyclic benzylidene acetal linker represented by formula (1) or formula (2), wherein Y is an antibody; D is a drug; Rand Rare each independently a hydrogen atom or a hydrocarbon group; R, R, Rand Rare each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; w is an integer of 1 to 20; and Zand Zare each independently a selected divalent spacer: 

Antibody-drug conjugate having cyclic benzylidene acetal linker

A hydrophilic polymer derivative having a benzylidene acetal linker whose hydrolysis rate at the pH of a weakly acidic environment in the living body can be accurately controlled. A hydrophilic polymer derivative having a benzylidene acetal linker, which is represented by the following formula (1): wherein Ris a hydrogen atom or a hydrocarbon group; R, R, R, R, and Rare each independently a hydrogen atom or a substituent and at least one of R, R, and Ris an electron-withdrawing substituent or at least one of Rand Rrepresents a substituent; Xis a chemically reactive functional group; P is a hydrophilic polymer; w is an integer of 1 to 8; and Zand Zare an independently selected divalent spacer.

Hydrophilic polymer derivative having benzylidene acetal linker

A lipid derivative in which a hydrophilic polymer is bound through a cyclic benzylidene acetal linker, and which can accurately control a hydrolysis rate in the weakly acidic environment of a living body to detach the hydrophilic polymer from a lipid membrane structure. The lipid derivative is represented by formula (1): wherein, Rand Rare each independently a hydrogen atom or a hydrocarbon group; R, R, Rand Rare each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; Ris a hydrocarbon group having from 8 to 24 carbon atoms, an acyl group having from 8 to 24 carbon atoms, a cholesterol derivative, a glycerolipid, a phospholipid or a sphingolipid; P is a hydrophilic polymer; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; and Zand Zare each independently a selected divalent spacer.

Lipid derivative in which hydrophilic polymer is bound through cyclic benzylidene acetal linker

Provided herein are narrowly distributed multi-armed polyethylene glycol compounds, and hydrogels containing the same. Also provided are methods for treating, adhering, or sealing a biological tissue with hydrogels, and kits for making a hydrogel. Drug releasing compositions also are provided that include a narrowly distributed multi-armed polyethylene glycol compound.

Narrowly distributed multi-armed polyethylene glycol compounds, hydrogels, and methods

A branched hetero polyethylene glycol according to the present invention is represented by the formula [1]: wherein X and Y represent each an atomic group containing at least a functional group which reacts with a functional group present in a bio-functional molecule to form a covalent bond and the functional group contained in the atomic group X and the functional group contained in the atomic group Y are different from each other; s is an integer of 2 to 8, which represents the number of polyethylene glycol chains; n is the number of average added moles for the polyethylene glycol chain and 20&#x2264;n&#x2264;2000; and E is a branching linker moiety having s-valent bonding valency for the polyethylene glycol chains and having monovalent bonding valency for the functional group Y.

Branched hetero polyethylene glycol and intermediate

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Tokyo, Japan

Yuji Yamamoto