Chugai Seiyaku Kabushiki Kaisha

Yuji Wakahara

Koh Sato

Masaaki Kosaka

Naohiro Yabuta

Shuji Ozaki

An inducing agent or enhancing agent, for the expression of HM1.24 antigen in hematopoietic tumor cells, comprising interferon &#x3b1;, interferon &#x3b3;, or the IRF-2 protein as an active ingredient, as well as an antitumor agent for hematopoietic tumors which comprises a combination of said inducing agent or enhancing agent and an antibody against HM1.24.

Therapeutic agent for hematopoietic tumors

An enhancer of expression, in the myeloma cell, of HM1.24 antigen, said enhancer comprising interferon-&#x3b1; or interferon-&#x3b3;, or IRF-2 protein as an active ingredient. Interferon-&#x3b1; or interferon-&#x3b3; is expected to enhance the expression of HM1.24 antigen by activating the promoter of a gene encoding HM1.24 antigen.

Method for treating myeloma utilizing an expression enhancer for HM1.24 antigen

An inducing agent or enhancing agent, for the expression of HM1.24 antigen in hematopoietic tumor cells, comprising interferon &#x3b1;, interferon &#x3b3;, or the IRF-2 protein as an active ingredient, as well as an anti-tumor agent for hematopoietic tumors which comprises a combination of said inducing agent or enhancing agent and an antibody against HM1.24.

Disclosed are an antibody against human para-thyroid-hormone-related protein, a DNA coding for the antibody, a recombinant vector containing the DNA, a transformant transformed with the recombinant vector, a method for preparation of the antibody, and uses of the antibody.

Growing community of inventors

Gotenba, Japan

Yuji Wakahara