Fujisawa Pharmaceutical Company, Ltd.

Yuji Tokunaga

Takehisa Hata

Akira Kagayama

Saburo Murata

Fumio Shiomojo

Masashi Hashimoto

Hiroshi Kayakiri

Satoshi Ueda

Hidekazu Takeno

Fumio Shimojo

Takao Yamamoto

Sumihisa Kimura

Takeo Hirose

Sachiyo Tanimoto

Atsunori Kaibara

Tomoaki Iwasa

Aerosol compositions

The use of a medium-chain fatty acid triglyceride as the dispersant in the preparation of a medicinal aerosol composition comprising tricyclic compound (I) dispersed in a liquefied hydrofluoroalkane propellant is described. When a liquefied hydrofluoroalkane is added to a kneaded premix of the tricyclic compound (I) and a medium-chain fatty acid triglyceride, the active ingredient is evenly dispersed in the liquefied hydrofluoroalkane. Therefore, by distributing a dispenser first with the kneaded premix and, then, with a liquefied hydrofluoroalkane under cooling or elevated pressure, there can be provided a medicinal aerosol composition having an improved uniformity of content of the active ingredient.

To provide a pharmaceutical composition comprising a water-insoluble active substance, surfactant(s) and solid carrier(s), which is improved in dissolution and oral absorption characteristics.

Medicinal composition

A liposome preparation containing an immunosuppresive tricylic compound or a pharmaceutically acceptable salt thereof. Since the tricyclic compound is entrapped stably and quantitatively into the liposomes, a broad variety of drug forms and pharmaceutical preparations insuring a long duration of efficacy can be provided.

Liposome preparation containing a tricyclic compound

The present invention relates to liposome preparations. In particular, the present invention relates to Adriamycin-entrapped liposome preparations comprising cholesterol derivatives having a negative charge as a liposome membrane constituent. Adriamycin-entrapped liposome preparations have many uses in the medical field such as maintaining high Adriamycin blood levels over a long period of time and reducing systemic toxicity, for example.

Liposome preparation

The invention relates to a novel prodrug compound useful in the treatment of tumors, of the formula:

Prodrug compounds, process for the preparation thereof and sustained

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Sanda, Japan

Yuji Tokunaga