Sony Corporation

Yuji Segawa

Takeshi Nogami

Masahiro Matsumoto

Shuzo Sato

Akira Yoshio

Tasuku Yotoriyama

Naoki Komai

Shinichi Kai

Hidetoshi Watanabe

Toshio Watanabe

Hiizu Ootorii

Noriyuki Kishii

Masatoshi Suzuki

Tomoteru Abe

Masao Ishihara

Zenya Yasuda

Masaki Sato

Yoshiaki Kato

Akio Yasuda

Atsushi Fukumoto

Hiroshi Horikoshi

Isao Ichimura

Makoto Ito

Toshiki Moriwaki

Katsumi Watanabe

Satomi Tanaka

Tomohiko Nakamura

Junji Kajihara

Takuro Yamamoto

Naohisa Sakamoto

Kensuke Kojima

Eiji Saito

Akira Yoshiq

Minoru Tazoe

Mayumi Shiono

Noriyuki Kishi

Disclosed herein is a microchip that allows a sample to be introduced into a region easily and accurately, and which makes it possible to obtain high analysis accuracy. The microchip includes an airtight region into which a solution is externally introduced; and positioning means for positioning a channel for injecting the solution into the region by penetrating a substrate layer forming the region with respect to a puncture part of the region.

Microchip

Disclosed herein is an optical detector at least including: a first substrate in which a plurality of wells are formed; a second substrate in which a heating section is provided to heat the wells; a third substrate in which a plurality of photoirradiation sections are provided in alignment with the wells; and a fourth substrate in which a plurality of photodetection sections are provided in alignment with the wells.

Optical detector

A microchip is provided. The microchip includes a substrate structure including a fluid channel configured to contain a sample solution, wherein the fluid channel is maintained at a pressure lower than atmospheric pressure prior to injection of the sample solution into the fluid channel.

Microchip and method of producing microchip

A nucleic acid amplifier for carrying out a nucleic acid amplification reaction is disclosed. The amplifier includes a plurality of wells configured to carry out the nucleic acid amplification reaction. The amplifier also include a heating unit provided for every well. The amplifier further includes a light source for irradiating excitation light of a specified wavelength to all of the wells. A fluorescence detection unit is provided for every well.

Nucleic acid amplifier

A microchip is provided. The microchip (A) includes a substrate structure including a fluid channel () configured to contain a sample solution, wherein the fluid channel is maintained at a pressure lower than atmospheric pressure prior to injection of the sample solution into the fluid channel.

A sample solution introduction kit and a sample solution injector capable of introducing sample solution while reducing the rate of occurrence of an air bubble and having a simplified structure are proposed. A sample solution introduction kit includes a plate-like member and a sample solution injector. The plate-like member has a plurality of spaces formed therein and serving as reaction field and a communication space that communicates with the plurality of spaces therein and that has a portion defining an opening formed in a surface of the plate-like member, and the sample solution injector includes a container containing the sample solution, a tube that communicates with the bottom of the container and that is insertable into the opening, a stopper removably fitted into an opening formed at a top end of the tube, and liquid held in the container, and the liquid is insoluble in the sample solution and is lighter than the sample solution.

Sample solution introduction kit and sample solution injector

A nucleic acid quantification method that uses a microchip for nucleic acid amplification reaction, the microchip including an inlet through which a liquid is introduced from outside, a plurality of reaction regions provided as reaction sites of a nucleic acid amplification reaction, and a channel through which the liquid introduced through the inlet is supplied into each of the reaction regions, wherein the likelihood of the nucleic acid amplification reaction varies between the reaction regions, includes: flowing a detection target nucleic acid chain-containing solution through the channel and introducing the solution into each of the reaction regions to perform a nucleic acid amplification reaction; and detecting an amplification product in each of the reaction regions to specify the reaction regions in which the nucleic acid amplification reaction occurred.

Nucleic acid quantification method and microchip for nucleic acid amplification reaction

Disclosed herein is a light detection device including, at least, a substrate provided with a plurality of detection regions where to perform detection of fluorescent light emitted from the inside of a sample upon irradiation of the sample with light, a light irradiation section operable to perform the irradiation with light, an optical control section configured to irradiate the detection regions with the light radiated from the light irradiation section, and a light detection section operable to detect the fluorescent light.

Light detection device

A real-time PCR system for detecting gene expression levels includes plural reaction regions, a like plural number of heating portions arranged corresponding to the reaction regions and having heat sources, respectively, an optical unit capable of irradiating exciting light of a specific wavelength to all of the plural reaction regions, and a like plural number of fluorescence detecting portions arranged corresponding to the reaction regions, respectively. The heating portions are each provided with a temperature detector for detecting a temperature in a vicinity of the corresponding heat source and converting the temperature into an electrical signal and also with a controller for controlling a thermal dose from the corresponding heat source based on a correlation between electrical signals and calorific values of the heat source stored beforehand.

Real-time PCR system

A hybridization detecting unit which includes a reaction region in which hybridization takes place, a plurality of sites (e.g., the surface of electrodes) arranged in the reaction region to which is fixed a nucleic acid for detection, and means for sequentially moving by dielectrophoresis the target nucleic acid introduced into the reaction region according to the order of arrangement of the sites to which is fixed a nucleic acid for detection. A sensor chip provided with the hybridization detecting unit. The detecting unit compulsorily moves the target nucleic acid into the region where a probe nucleic acid for detection exists, thereby increasing the probability of hybridization taking place.

Hybridization detecting unit relying on dielectrophoresis and sensor chip provided with the detecting unit

A method of production and a method of polishing a semiconductor device and a polishing apparatus, capable of easily flattening an initial unevenness of a metal film, excellent in efficiency of removal of an excess metal film, and capable of suppressing damage to an interlayer insulation film below the metal film when flattening the metal film by polishing, the polishing method including the steps of interposing an electrolytic solution including a chelating agent between a cathode member and the copper film, applying a voltage between the cathode member used as a cathode and the copper film used as an anode to oxidize the surface of the copper film and forming a chelate film of the oxidized copper, selectively removing a projecting portion of the chelate film corresponding to the shape of the copper film to expose the projecting portion of the copper film at its surface, and repeating the above chelate film forming step and the above chelate film removing step until the projecting portion of the copper film is flattened.

Methods of producing and polishing semiconductor device and polishing apparatus

A method of producing a semiconductor device capable of suppressing damages by corrosion on wiring in a catalyst process performed in electroless plating processing on a Co base material, etc. in producing a semiconductor device having wiring of Cu, etc., having steps of forming metal wiring including an additive on a first insulation film formed in a semiconductor substrate, and forming on the metal wiring a barrier layer for preventing diffusion of constituting elements of the metal wiring, wherein said additive is an element to reduce corrosion of the metal wiring at the time of forming the barrier layer in the step of forming the metal wiring.

Method of producing a semiconductor device having copper wiring

Concentration of electric current due to an additive (particularly, a brightener) remaining or precipitated in a high concentration at grain boundary triple points and wiring groove portions in the surface layer of a copper plating film is obviated, whereby precedent dissolution and/or abnormal dissolution due to concentration of electric current is restrained, and an electropolished surface of the copper plating film with excellent surface smoothness is obtained. A method of producing a metallic film includes the steps of: forming a metallic plating film (copper plating film ()) by use of a plating solution prepared by adding a plating additive for restraining void generation, bottom-up fill and overfill; and electropolishing the metallic plating film by use of an electropolishing solution prepared by adding a polishing additive capable of reacting or coupling with the plating additive component contained or precipitated in the surface layer of the metallic plating film.

Growing community of inventors

Tokyo, Japan

Yuji Segawa