Otsuka Pharmaceutical Company, Limited

Yuji Ochi

Takayuki Matsuzaki

Kenji Otsubo

Takahito Yamauchi

Atsushi Mori

Masami Nakai

The present invention provides a quinolone compound represented by General Formula (1) or a salt thereof, wherein Rrepresents a hydrogen atom, etc.; Rrepresents a hydrogen atom, etc.; Rrepresents a phenyl group optionally being substituted with one or more substituents, etc.; Rrepresents a halogen atom; Rrepresents a hydrogen atom or halogen atom; Rrepresents a hydrogen atom; and Rrepresents a hydroxyl group, etc. The quinolone compound have a functional improvement effect, which suppresses progression of neurological dysfunction by inhibiting the chronic progression of Parkinson's disease or protecting dopamine neurons from the disease etiology, thereby prolonging the period before first administration begins.

Quinolone compound and pharmaceutical composition

The present invention provides a quinolone compound that inhibits the chronic progression of Parkinson's disease or protects dopamine neurons from disease etiology, thereby suppressing the progression of neurological dysfunction, so as to prolong the period of time until L-dopa is administered while also improving neuronal function; the quinolone compound of the invention is represented by Formula (1): wherein:

Growing community of inventors

Osaka, Japan

Yuji Ochi