Nissan Chemical Industries Limited

Yuji Moriyama

Manabu Yaosaka

Kazutaka Matoba

Takashi Mizukoshi

Tomohisa Utsunomiya

Tomohiro Matsumoto

Eitatsu Ikeda

Ken-ichi Toyama

Hiroyuki Kousaka

Shunsuke Fukuya

There is provided a novel intermediate for producing pesticides. A method for producing the compound of Formula (3) comprises reacting an aromatic ketone compound of Formula (4) and a substituted acetophenone compound of Formula (5) as starting raw materials in an organic solvent or water in the presence or absence of an additive in the presence of a base in a suspended state. A method may comprise dehydrating the compound of Formula (3). A method for producing compound (2) in one step comprises reacting compound (4) and compound (5) to obtain compound (3). Further, a method for producing an isoxazoline compound of Formula (1) comprises reacting compound (2) and a hydroxylamine in an aliphatic or an aromatic hydrocarbon solvent which is optionally substituted by a halogen atom by adding an additive selected from a phase-transfer catalyst, a C-Calcohol and an aprotic polar solvent in the presence of a base and water.

Method for production of 3-hydroxypropan-1-one compound, method for production of 2-propen-1-one compound and method for production of isoxazoline compound

There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an &#x3b1;,&#x3b2;-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method. 

Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound

There is provided a novel intermediate for producing pesticides. A method for producing the compound of Formula (3) comprises reacting an aromatic ketone compound of Formula (4) and a substituted acetophenone compound of Formula (5) as starting raw materials in an organic solvent or water in the presence or absence of an additive in the presence of a base in a suspended state. A method may comprise dehydrating the compound of Formula (3). A method for producing compound (2) in one step comprises reacting compound (4) and compound (5) to obtain compound (3). Further, a method for producing an isoxazoline compound of Formula (1) comprises reacting compound (2) and a hydroxylamine in an aliphatic or an aromatic hydrocarbon solvent which is optionally substituted by a halogen atom by adding an additive selected from a phase-transfer catalyst, a C-Calcohol and an aprotic polar solvent in the presence of a base and water. 

A production method of an isoxazoline-substituted benzoic acid amide compound of Formula (1) where X is a halogen atom, Chaloalkyl, etc., Y is a halogen atom, Calkyl, etc., Ris a Chaloalkyl, etc., Rand Rindependently of each other are a hydrogen atom, Calkyl, etc., Ris Calkyl, Chaloalkyl, etc., Ris a hydrogen atom, Calkyl, etc., m is an integer of 0 to 5, n is an integer of 0 to 4, including: reacting an isoxazoline-substituted benzene compound of Formula (3) where X, Y, R, m, and n are the same as defined above, L is a chlorine atom, a bromine atom, &#x2014;C(O)OH, &#x2014;C(O)J, etc., J is a halogen atom, with a 2-aminoacetic acid amide compound of Formula (2) where R, R, R, and Rare the same as defined above, or a salt thereof; crystal forms and the production method thereof.

Production method of isoxazoline-substituted benzoic acid amide compound

A production method of an isoxazoline-substituted benzoic acid amide compound of Formula (1) where X is a halogen atom, Chaloalkyl, etc., Y is a halogen atom, Calkyl, etc., Ris a Chaloalkyl, etc., Rand Rindependently of each other are a hydrogen atom, Calkyl, etc., Ris Calkyl, Chaloalkyl, etc., Ris a hydrogen atom, calkyl, etc., m is an integer of 0 to 5, n is an integer of 0 to 4, including: reacting an isoxazoline-substituted benzene compound of Formula (3) where X, Y, R, m, and n are the same as defined above, L is a chlorine atom, a bromine atom, &#x2014;C(O)OH, &#x2014;C(O)J, etc., J is a halogen atom, with a 2-aminoacetic acid amide compound of Formula (2) where R, R, R, and Rare the same as defined above, or a salt thereof; crystal forms and the production method thereof. 

There is provided a novel process for production of a 2-(substituted phenyl) -3,3,3-trifluoropropene.  Disclosed is a process for production of a 2-(substituted phenyl)-3,3,3-trifluoropropene compound represented by the formula (7) or a salt thereof The process comprises reacting a compound represented by the formula (1) (X is an alkyl group, etc.) with a compound represented by the formula (2) (Y is a halogen atom, etc.) in the presence of a catalyst represented by the formula (3) (M is an ion of a metal belonging to Group 10 on the elementary periodic table which has an oxidation state number of 1 to 8; G is a unidentate or multidentate ligand; L is a phosphine compound represented by the formula (4) which is bound to the center metal M or is a carbene selected from those represented by the formulae (5) and (6), provided that L's may be same as or different from one another when a is 2 to 5; A represents a univalently or multivalently charged anion; b represents an integer of 1 to 3; a represents an integer of 1 to 5&#xb7;b; c represents 0 or an integer of 1 to 4&#xb7;b; and n represents an integer of 1 to 6).

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Funabashi, Japan

Yuji Moriyama