Meiji Seika Kaisha, Ltd.

Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai

Yuji Matsuhashi

Shinichi Kondo

Seiji Shibahara

Takashi Tsuruoka

Shigeharu Inouye

Takaaki Aoyagi

Kiyoaki Katano

Mitsugu Hachisu

Satoru Nakabayashi

Fumiya Hirano

Haruo Yamamoto

Tomoya Machinami

Yasukatsu Yuda

Motohiro Nishio

Shigeharu Inoye

Tomio Takeuchi

Kazue Yasufuku

Yukiko Takahashi

Takashi Tsuroka

A novel benzothiazole or benzimidazole derivative represented by formula (I) ##STR1## wherein X represents a sulfur atom or a NH group; R.sup.1 represents a hydrogen atom, a lower alkoxy group, a chlorine atom, a bromine atom or an iodine atom; R.sup.2 represents a hydrogen atom a substituted or unsubstituted lower alkyl group, a vinyl group, an aryl group or an acyl group; m is an integer of 1, 2 or 3; and n is an integer of 0, 1 or 2, which shows an excellent acid secretion suppressing effect and gastric mucosa protecting effect, and an antiulcer agent containing the same as an active ingredient.

Benzothiazole and benzimidazole derivatives and antiulcer agent

A therapeutic and/or prophylactic agent for viral infection, particularly human immunodeficiency virus (HIV) infection, which comprises as an active ingredient a lactam compound represented by formula (I) ##STR1## wherein X represents --COOR, wherein R represents a hydrogen atom or a straight-chain or branched-chain alkyl group having from 1 to 8 carbon atoms, or ##STR2## wherein n represents an integer of 2 or 3 and A represents methine when n is 2 or a quarternary carbon atom when n is 3, or a pharmaceutically acceptable salt or ester derivative thereof.

Antiviral agent containing lactam compound

As new compounds are provided a class of derivatives of actinonin represented by the general formula ##STR1## where R is a hydrogen or a lower alkyl group, which can exhibit the enzyme-inhibitory activities to a limited range of peptidases and show a remarkable enzyme-specificity, and which are effective to treat a cycloheximide-induced experimental amnesia in mice and are expectable to be useful to treat an amnesia in a mammalian animal, including human.

Actinonin derivatives having physiological activities

Growing community of inventors

Kanagawa, Japan

Yuji Matsuhashi