Ajinomoto Co., Ltd.

Yuji Iwashita

Katsumi Ajisaka

Keiji Iwasaki

Akira Yabuki

Taketoshi Okami

Superoxide dismutase is chemically modified with poly(alkylene oxide), the modified superoxide dismutase having a molecular structure in which both ends of a poly(alkylene oxide) molecule are attached to superoxide dismutase. The modified superoxide dismutase can be used to remove toxic substances derived from oxygen, from the blood circulation in a living body, and has a longer half life in the blood circulation as compared to superoxide dismutase which has not been modified.

Superoxide dismutase combined with a poly(alkylene oxide)

There is disclosed hemoglobin modified in that a poly(alkylene oxide) is bonded thereto by a bond between a terminal group of said poly(alkylene oxide) and an amino group of said hemoglobin, said bond having the structure:

Hemoglobin combined with a poly(alkylene oxide)

An oxygen carrying material containing hemoglobin or a hemoglobin derivative covalently coupled through an amide bond to a polymer selected from the group consisting of polyethylene glycol, polypropylene glycol, and copolymers of ethylene oxide and propylene oxide.

Oxygen carrier

A hemoglobin modified by covalently bound inulin.

Oxygen carrier for blood substitute

A novel modified hemoglobin was prepared. The hemoglobin is coupled with a polyalkylene glycol or its derivative, and the products are useful as a blood substitute. The oxygen-carrying capacity of this hemoglobin is nearly equal to that of a native hemoglobin, and the residence time in the circulation is satisfactorily long.

Growing community of inventors

Kawasaki, Japan

Yuji Iwashita