Tobira Therapeutics, Inc.

Takeda Chemical Industries, Inc.

Takeda Pharmaceutical Company Limited

Yuji Iizawa

Masaki Seto

Mitsuru Shiraishi

Masanori Baba

Naoyuki Kanzaki

Katsuji Aikawa

Shohei Hashiguchi

Tomoyasu Ishikawa

Yoshio Aramaki

Naoki Miyamoto

The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula: wherein, Ris a 5- to 6-membered ring group which may be substituted; Xis a bond or the like; ring A is a 5- to 6-membered ring group which may be substituted; ring B is a 8- to 10-membered ring group which may be substituted; Xis a bivalent group of 1 to 4 atom; Zis a bivalent cyclic ring group or the like; Zis a bond or the like; and Ris an amino group, a nitrogen-containing heterocyclic group which may be substituted or the like, or a salt thereof.

Bicyclic compound, production and use thereof

The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula: wherein, Ris a 5- to 6-membered ring group which may be substituted; Xis a bond or the like; ring A is a 5- to 6-membered ring group which may be substituted; ring B is a 8- to 10-membered ring group which may be substituted; Xis a bivalent group of 1 to 4 atoms; Zis a bivalent cyclic ring group or the like; Zis a bond or the like; and Ris an amino group, a nitrogen-containing heterocyclic group which may be substituted or the like, or a salt thereof.

A cephem compound (particularly its crystal) represented by the formula [I], wherein X is CHCOOH, CHCHCOOH or CHCN, and n is 0 to 5, is useful as an antibacterial agent (particularly anti-MRSA agent) and shows superior quality such as high solid stability, possible long-term stable preservation and the like. 

Phosphonocephem compound

The present invention provides a novel benzazepine derivative represented by formula: wherein, Ris a 5- or 6-membered aromatic ring, Ris lower alkyl group, etc., Y is an optionally substituted imino group, ring A and ring B are independently an optionally substituted aromatic ring, W is formula &#x2014;W&#x2014;X&#x2014;W&#x2014; (Wand Ware independently S(O)(m1 is 0, 1, or 2), etc., and Xis an optionally substituted alkylene group etc.), a preparation method and use thereof.

Benzazepine derivative, process for producing the same, and use

A cephem compound (particularly its crystal) represented by the formula [I], wherein X is CHCOOH, CHCHCOOH or CHCN, and n is 0 to 5, is useful as an antibacterial agent (particularly anti-MRSA agent) and shows superior quality such as high solid stability, possible long-term stable preservation and the like.

Growing community of inventors

Muko, Japan

Yuji Iizawa