Kowa Company Limited

Honda Giken Kogyo Kabushiki Kaisha

Yuichiro Watanabe

Kimiyuki Shibuya

Takayuki Matsuda

Sayaka Kurobuchi

Ayumu Okuda

Yuki Yamaguchi

Minoru Koura

Takashi Enomoto

Hisashi Sumida

Toru Miura

Koichi Yamazaki

Takeshi Imai

Satoshi Murata

Hidefumi Ozawa

Ayako Tosaka

Sayaka (deceased) Kurobuchi

[Object] It is to provide a novel LXR&#x3b2; agonist useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate: (wherein, each V and W independently show N or C&#x2014;R; each X and Y independently show CH, C&#x2550;O, SO, etc; Z shows CH or N; each R, Rand Rindependently show a hydrogen atom, Calkyl group, etc.; Rshows Calkyl group; Rshows an optionally substituted Caryl group or an optionally substituted 5- to 11-membered heterocyclic group; Rand Rshow a hydrogen atom, etc.; L shows a Calkyl chain optionally substituted with an oxo group, etc.; and n shows any integer of 0 to 2.)

Carbinol derivatives having heterocyclic linker

[Object] To provide a novel LXR&#x3b2; agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate. 

Carbinol derivatives having cyclic linker

To provide a novel LXR&#x3b2; agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. A quinoline compound represented by the following general formula (1) or salt thereof, or their solvate. 

Quinoline compounds

The object is to provide a novel LXR&#x3b2; agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. The solving means is a 1,3-dihydroisobenzofuran derivative represented by the following general formula (1) or salt thereof, or their solvate. 

1,3-dihydroisobenzofuran derivatives

To provide a novel LXR&#x3b2; agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A 2-oxochromene derivative represented by the following general formula (1) or salt thereof, or their solvate. 

2-oxochromene derivatives

An e-mail sending and receiving system in which positional data about a plurality of places can be included in an e-mail message to be sent, and further detailed data can be obtained based on the included positional data, thereby improving the convenience and effectiveness of the positional data. The system includes a mail generating section for generating an e-mail message to be sent to an addressee; a positional data storage section for storing a plurality of positional data; and a positional data attaching section for attaching one or more of the positional data stored in the positional data storage section to the e-mail message generated by the mail generating section. The system may further include a section for generating detailed data relating to each positional data attached to the e-mail message, and attaching a URL for accessing the detailed data to the e-mail message.

System for sending and receiving e-mail to which a plurality of positional data are attachable

Growing community of inventors

Tokyo, Japan

Yuichiro Watanabe