Kawasaki Steel Corporation

Pacific Steel Mfg. Co., Ltd.

Fujifilm Corporation

Yuichiro Sato

Akira Yorifuji

Taro Kanayama

Satoshi Matsuoka

Shoitsu Seo

Toshiaki Kasuya

Takashi Tamura

Hiyoku Nakata

Hidenobu Kuniyoshi

Shinsuke Mizumoto

Yasutaka Baba

Kimihiko Sato

Mari Yamamoto

Hideki Kurihara

Hideyasu Fujiwara

Shinji Hagiwara

Yohei Kubo

An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein Rrepresents a halogen atom; Rrepresents a Calkyl group, a Calkenyl group, a Calkynyl group, a Ccycloalkyl group, an aryl group, an ar-Calkyl group or a heterocyclic group, each optionally having at least one substituent; Rrepresents an aryl group or a heterocyclic group each optionally having at least one substituent; and Rand Reach independently represent a hydrogen atom; and Rand Rmay form a cyclic amino group optionally having at least one substituent together with the nitrogen atom to which they bind) or a salt thereof, and a pharmaceutical composition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.

Nicotinamide derivative or salt thereof

A forged roll for rolling a seamless steel pipe, having excellent biting properties and wear resistance, and manufacturing method. The forged roll comprises a high carbon alloy cast steel comprising about 1.10-1.85 wt % carbon, about 0.3-1.2 wt % silicon, about 0.4-1.5 wt % manganese, about 0.5-2.0 wt % nickel, about 0.5-2.0 wt % chromium and iron. Heat treatment for spheroidal carbide formation is performed so that the spheroidal carbide covers about 35-55% of the area of the roll metallurgical structure.

Forged roll for rolling a seamless steel pipe and manufacturing method

A forged roll for rolling a seamless steel pipe, having excellent biting properties and wear resistance. The forged roll includes a high carbon alloy cast steel comprising about 1.10-1.85 wt % carbon, about 0.3-1.2 wt % silicon, about 0.4-1.5 wt % manganese, about 0.5-2.0 wt % nickel, about 0.5-2.0 wt % chromium and iron. Heat treatment for spheroidal carbide formation is performed so that the spheroidal carbide covers about 35-55% of the area of the roll metallurgical structure.

Forged roll for rolling a seamless steel pipe

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Toyama, Japan

Yuichiro Sato