Arkray, Inc.

Kyoto Institute of Technology

National University Corporation Kyoto Institute of Technology

Yuichiro Noda

Shigeru Kitamura

Takayuki Taguchi

Konomu Hirao

Yoshiyuki Tanaka

Takatoshi Uchigaki

Toshihiko Harada

Toshio Takama

Hidetoshi Kotera

Akira Murakami

Takaaki Suzuki

Naoyuki Nakanishi

Kensuke Kanda

Masayuki Kondo

Asako Yamayoshi

Akio Kobori

Teru Okitsu

Shogo Nagata

Takashi Osumi

Taku Matsumura

Atsuhito Okonogi

Kazuya Tatsumi

Takashi Tada

Ryuji Yokokawa

The present invention provides a novel target analysis chip and analysis method for directly detecting a target such as a microRNA without performing PCR.

Target analysis chip and target analysis method

To provide a cell culture device, a cell culture system and a cell culture method capable of suppressing fluctuations in pressure in a culture fluid, and suppressing gas bubbles from flowing into a cell culture section. A cell culture device including: a cell culture section that cultures cells; a storage section that stores a culture fluid; flow paths that connect the cell culture section and the storage section; a fluid delivery device that is provided at the flow paths and that delivers the culture fluid from the storage section to the cell culture section; a pressure equalizing unit that is provided at the flow paths and that suppresses fluctuations in pressure imparted to the culture fluid delivered to the cell culture section; and a pressurization unit that is provided at the flow path at a flow outlet side of the cell culture section and that applies a specific pressure to the culture fluid.

Cell culture device, cell culture system, and cell culture method

A fluid agitation method is provided, whereby a swirling flow is generated in a trace amount of fluid, thereby agitating the fluid. The fluid agitation method includes introducing the fluid into an agitation chamber () including a wall having an uneven mass distribution, and applying oscillation (F) to the wall with frequencies varying in a predetermined frequency range. The uneven mass distribution of the wall is attained, for example, by arranging a plurality of thickened portions (to) of different thicknesses in a ring.

Fluid agitation method, fluid agitation system, and cartridge

This invention relates to technology for analyzing a specific component in a sample liquid, and provides an analyzing tool and an analyzing apparatus. Analyzing tool (Y) includes a liquid inlet () at a central portion of the tool and a plurality of channels () which communicate with liquid inlet () and move the sample liquid introduced through liquid inlet () by capillary action from the central portion towards a peripheral portion of the tool. Each channel () extends linearly for example from the central portion towards the peripheral portion, and the plurality of channels () are arranged radially.

Analyzing tool and device

A liquid feeding method for feeding liquid in a minute flow path is provided. The minute flow path includes flow pathsconnected to each other directly at respective first ends. The liquid feeding direction of blood S in the minute flow path is controlled by creating a high-pressure state at a second end of the flow pathlocated across the blood S, while creating a low-pressure state or a closed state at a second end of the flow paths

Liquid feeding method and cartridge to be used therein

An analyzing tool (Y) has a liquid-introducing opening (), one or more flow passages () through which a sample liquid introduced from the liquid-introducing opening () is moved, and a separation film () for filtrating the sample liquid supplied to the liquid-introducing opening () and then introducing the liquid filtrated to the one or more flow passages (). The analyzing tool (Y) is structured such that a liquid sample is filtrated by being advanced in the thickness direction of the separation film (). The flow passage () is structured such that the sample liquid is moved by, for example, a capillary phenomenon.

Analytical tool

The invention relates to a method of producing an analytical tool having recesses () formed therein for moving a sample liquid, a base plate () made of polymeric material, and a cover laminated to the base plate () to cover the recesses (). This producing method includes the step of applying a hydrophilic treatment to the inner surfaces of the recesses (). The hydrophilic treatment includes a primary modifying operation for primarily modifying the properties of the inner surfaces of the recesses () by contacting a modifying gas with the inner surfaces of the recesses (), and a secondary modifying operation for secondarily modifying the properties of the inner surfaces of the recesses ().

Method of producing analytical tool

A blood testing tool is provided, which can recover blood plasma or blood serum with a high yield without causing hemolysis of blood cells. A recovery porous membraneto be impregnated with blood serum or blood plasma contained in blood and retain it and a separation porous membranefor separating blood cells from the blood are provided. The separation porous membraneis laminated on the recovery porous membranewhile satisfying the condition that pores on an upper surface side of the recovery porous membrane have an average pore size that is in a range from 10 to 1000 &#x3bc;m and is larger than that of pores on a lower surface side of the separation porous membrane, thus providing a blood testing tool according to the present invention.

Blood examination instrument

A blood testing tool is provided, which separates blood cells and can collect blood plasma or blood serum with a high yield. The blood testing tool includes an asymmetric porous membrane with a pore size distribution in which an average pore size varies to be reduced continuously or discontinuously in a thickness direction. The porous membrane includes a blood supply portion, a development portion, and a blood-cell blocking portion formed between the blood supply portion and the development portion and pores in the blood cell blocking portion include only pores through which blood cells cannot pass. When blood is supplied to one side with larger pores of the blood supply portion, the blood moves in a direction parallel to a surface of the porous membrane by a capillary phenomenon, but only blood plasma or blood serum moves into the development portion to develop.

Blood testing tool

Amounts of components in a specimen can be analyzed with excellent quantitativity. The analysis includes: measuring an amount of a component to be analyzed in a specimen; measuring an amount of a standard component present originally and homeostatically in the specimen other than the component to be analyzed; determining the amount of the specimen from the amount of the standard component thus measured and a known concentration of the standard component in the specimen; and determining a concentration of the component to be analyzed in the specimen from the amount of the specimen thus determined and the amount of the component to be analyzed thus measured. The quantitative analysis of the present invention allows a component to be analyzed to be measured with high quantitativity as shown in FIG.

Growing community of inventors

Kyoto, Japan

Yuichiro Noda