Teikoku Seiyaku Co., Ltd.

Ibsa Institut Biochimique Sa

Yuichiro Mabuchi

Takashi Kamakura

Kenichi Hattori

Taiki Shibata

Kazuha Tani

Kazuhito Okada

An aqueous patch containing diclofenac sodium, wherein the patch contains a homogeneous mixed solution of diclofenac sodium, wherein the solution is obtained by mixing crotamiton, diclofenac sodium and water in the mixture ratio of crotamiton/diclofenac sodium of 8.0 or less and the mixture ratio of (water+crotamiton)/diclofenac sodium of 3.0-20.0.

Aqueous patches containing diclofenac sodium

An external patch containing diclofenac hydroxyethylpyrrolidine prepared by laminating an adhesive layer on a backing, wherein said adhesive layer is characterized by comprising 5-50% by weight of styrene&#x2022;isoprene&#x2022;styrene block copolymer, 20-50% by weight of a tackifier resin, 5-70% by weight of a softening agent, and 0.5-20% by weight of one or more solubilizers selected from N-methyl-2-pyrrolidone, propylene glycol and dimethyl sulfoxide as essential ingredients, and 0.5-20% by weight of diclofenac hydroxyethylpyrrolidine as an active ingredient. The patch has excellent transdermal absorption, less skin-irritation and excellent stability of the drug.

Anti-inflammatory analgesic adhesive patch for external use

Growing community of inventors

Higashikagawa, Japan

Yuichiro Mabuchi