Hitachi-high-technologies Corporation

Hitachi, Ltd.

Hitachi High-tech Corporation

Olympus Corporation

Roche Diagnostics Operations, Inc.

Applera Corporation

Roche Diagnostics Gmbh

F. Hoffmann-la Roche Ag

Yuichiro Hashimoto

Hideki Hasegawa

Masuyuki Sugiyama

Izumi Waki

Masao Suga

Hiroyuki Satake

Yasuaki Takada

Takashi Baba

Masuyoshi Yamada

Minoru Sakairi

Hidetoshi Morokuma

Hisashi Nagano

Shun Kumano

Hideo Kashima

Masakazu Sugaya

Koichi Terada

Kiyomi Yoshinari

Hiroyuki Yasuda

Yasutaka Suzuki

Nobuhiro Tsukada

Kazushige Nishimura

Yohei Kawaguchi

Daisuke Akieda

Yasunori Doi

Shuhei Hashiba

Yusuke Yota

Takayuki Nabeshima

Kyoko Kojima

Masahito Togami

Hideyuki Kawanabe

Kentaro Yamazaki

Sho Iwasa

Riku Tamura

Yuka Sugawara

Yuka Sumigama

Yoshiaki Kato

Marvin L Vestal

Takashi Yoneyama

Atsumu Hirabayashi

Yasushi Terui

Toshiyuki Yokosuka

Ryuichi Hirano

Kinya Kobayashi

Jun Maeda

Tetsuya Shirota

Tomoyuki Tobita

Makoto Nogami

Shin Imamura

Masamichi Tsukada

Mamoru Mizumoto

Takuma Nishimoto

Keigo Takahashi

Shinya Matsuoka

Tsukasa Shishika

Atsushi Ootake

Akihiko Okumura

Keiji Okada

Masami Sakamoto

Masako Ishimaru

Daisuke Ebihara

Jin Ohara

Hiroshi Touda

Hiroki Mizuno

Jiro Tokita

Isao Furuya

Tatsuo Nojiri

Hiroyuki Inoue

Yukiko Hirabayashi

Akihito Kaneko

Zihao Ong

Aart Pieter Van Doorn

Yushi Harada

Yasutaka Iida

Tibor Toth

Yuki Nagaya

Midori Tobita

Stefan Quint

Masayuki Sugiyama

Satake Hiroyuki

An endoscope contamination detection device includes: a light source that irradiates an endoscope with light having a specific wavelength; an image sensor that receives fluorescence emitted by a deposit adhering to a surface of the endoscope; and a control device having a processor, wherein the processor acquires a signal from the image sensor, generates an image from the signal, detects luminance values of a plurality of pixels of the image, and determines a contamination degree of the endoscope, based on the luminance values.

Endoscope contamination detection device, control device, and endoscope contamination detection method

Provided is a technology for reducing the capacity of a liquid feeding pump and enabling liquid feeding with little pulsation. A liquid feeding pump according to the present disclosure is provided with: a first plunger pump having a first plunger; a second plunger pump having a second plunger and connected in series with the first plunger pump; a pressure sensor disposed downstream of the second plunger pump; and a control unit that accepts the input of a liquid discharge pressure measured by the pressure sensor and that controls the driving of the first plunger and the driving of the second plunger. The control unit calculates the rate of change in the pressure of the liquid on the basis of the past compression distances of the plunger for when the liquid was compressed by the first plunger pump and the pressure at the completion of compression, predicts the compression distance of the first plunger on the basis of the rate of change in pressure and the present discharge pressure, and determines the timing at which the compression performed by the first plunger will be completed on the basis of the predicted compression distance.

Liquid feeding pump and liquid feeding method

The present invention provides a technique that enables liquid feeding with small pulsation by reducing the volume of a liquid feeding pump. Disclosed is a liquid feeding pump comprising: a first plunger pump that has a first plunger; a second plunger pump that has a second plunger and is connected to the first plunger pump in series; a pressure sensor that is disposed on the downstream side of the second plunger pump; and a control unit that accepts an input of the discharge pressure of a liquid measured by the pressure sensor to control driving of the first plunger and driving of the second plunger, wherein when the first plunger pump compresses the liquid, the control unit drives the first plunger at a first speed, and then decreases the speed to a second speed slower than the first speed before the compression is completed, and wherein the control unit discharges the liquid from the second plunger pump by driving the second plunger in parallel with the driving of the first plunger.

A pretreatment method of an automatic analyzer, in which pretreatments of a plurality of substances to be measured can be performed by a series of treatments using a plurality of magnetic beads that can bind to the plurality of substances to be measured, is achieved. In the pretreatment method of an automatic analyzer, a magnetic bead is added to a sample containing a substance to be measured, the substance to be measured is bound to the magnetic bead, the magnetic bead is extracted from the sample, and the substance to be measured is separated from the magnetic bead by an eluate. A plurality of magnetic beads that bind to a plurality of types of substances to be measured are added to a sample, and the plurality of types of substances to be measured are extracted from the magnetic bead by an eluate.

Pretreatment method of an automatic analyzer

A flow path washing method and apparatus for an auto sampler in which, when a cleaning fluid supplied to a flow path which is switched between a first flow path including a nozzle for aspirating a sample and a sample loop for holding the aspirated sample, and a second flow path including a washing tub for washing at least an outer wall of the nozzle, a control unit changes a flow velocity of the cleaning fluid supplied between measurement of a first measurement item and measurement of a second measurement item based on washing information showing washing patterns corresponding to measurement items of the sample, including at least one of first washing information showing a washing pattern corresponding to the first measurement item of the sample and second washing information showing a washing pattern corresponding to the second measurement item to be measured subsequent to the first measurement item.

Flow path washing method of auto sampler and flow path washing apparatus of auto sampler

A control unit of a reprocessor main body includes a processor, the processor being configured to acquire a plurality of observation images, image pickup angles of which regarding a positioning state of an endoscope positioned in an endoscope reprocessor are different, select an image showing a first part that is a predetermined part inside the endoscope reprocessor and a second part that is a predetermined part of the endoscope, and determine whether the second part is included in a predetermined range from the first part.

Control apparatus, endoscope positioning state determination method, and non-transitory recording medium

There are provided an ion source that can accurately and efficiently grasp whether a tip end position on a capillary downstream side is proper and a control method therefor. An ion source according to an embodiment of the present invention measures an electric current generated due to the application of a voltage to a capillary by a power supply when a sample is not introduced into the capillary. When the electric current is within tolerance, the ion source outputs projection amount information expressing that the projection amount of the capillary is proper, and the ion source outputs the projection amount information expressing that the projection amount is improper when the projection amount is not within the tolerance.

Ion source, mass spectrometer, ion source control method

A mass spectrometer includes an ion source, an ion guide, a quadrupole mass filter, a detector, DC and RF power sources, and a voltage control device for controlling an acceleration voltage by controlling the power source. The voltage controller controls the acceleration voltage such that it is increased as the mass-to-charge ratio of ions to be measured is increased within a control region. The control region is surrounded, having one coordinate axis representing the mass-to-charge ratio of the ions passing the ion guide and another axis representing the acceleration voltage applied to the ion guide, by a line representing a lower limit of a stable region where the ions pass the ion guide stably, a line representing an ion mobility of the ions, an upper side representing an upper limit of the acceleration voltage, and a lower side representing a value at which the acceleration voltage is zero.

Mass spectrometry device control method, mass spectrometry system, and voltage control device

The present disclosure is related to an analytical system comprising a liquid chromatographic (LC) system comprising a plurality of fluidic streams alternately connectable to a common detector via a stream-selection valve connected to the detector via a valve-to-detector conduit. The analytical system further comprises a wash pump fluidically connected to the stream-selection valve and configured to connect to the valve-to-detector conduit between two consecutive fluidic streams in order to wash liquid from a previous fluidic stream out of the valve-to-detector conduit before liquid from a subsequent fluidic stream enters the valve-to-detector conduit. An analytical method comprising switching between the fluidic streams and washing in between is also disclosed.

Analytical system and method including switching between liquid chromatography fluidic streams

In a mass spectrometer, due to impurities accumulated inside a frame, a withstand voltage may decrease, and electric discharge may occur in an ion source, thereby making it impossible to perform normal measurement. Since a result of abnormality measurement due to the electric discharge cannot be distinguished from measurement abnormality caused by clogging of a tube between a pretreatment unit and a needle, there is a problem in that time is required to identify abnormal portions, and a maintenance property is lowered. As a unit for solving the problem, a return current detection unit connected in series between the frame and an ion source power supply that applies a voltage to the needle and a return current detection unit connected in series between the frame and a counter electrode power supply that applies a voltage to a counter electrode are provided.

Mass spectrometer and mass spectrometry method

Provided are an ion source and a mass spectrometer that reduce a dead volume of the connecting part of a pipe to a capillary. An ion source has a capillary and a pipe. The capillary has a large-diameter part that forms a capillary upstream-side end face on an upstream side. The large-diameter part has a large-diameter part downstream side face on a downstream side. The pipe has a pipe downstream end face on the downstream side. A capillary retaining unit has a hole through which the capillary downstream-side end face is passable and a face on which the large-diameter part downstream side face is installable. The ion source includes a pipe retaining unit that retains the pipe. The capillary retaining unit and the pipe retaining unit are disposed such that the capillary upstream-side end face contacts the pipe downstream end face to connect the capillary to the pipe.

Ion source and mass spectrometer

A liquid chromatographic apparatus which removes air bubbles during preparatory operation for apparatus startup includes a liquid feeding pump to feed a solvent, an injector to inject a sample into the solvent, a separation column to receive the solvent and the sample through the injector and separate the sample into components, a detector to detect the components supplied from the separation column, a pressure sensor to measure a pressure in a solvent flow channel of the liquid feeding pump, and a controller to control a purge operation for removing air bubbles in the solvent flow channel by the liquid feeding pump, determine whether a pressure change amount in the solvent flow channel measured by the pressure sensor during the purge operation is a specified change amount or larger, and complete the air bubble removal operation when the pressure change amount is the specified change amount or larger.

Liquid chromatographic apparatus and air bubble removal method of liquid chromatographic apparatus

The present invention relates to a liquid feeding apparatus capable of feeding a liquid with high accuracy. The liquid feeding apparatus includes a liquid feeder having a downstream side, a plunger, and a cylinder that is configured for aspirating and discharging a solvent when a plunger slides. The liquid feeding apparatus further includes a pressure sensor for the solvent to be discharged, a selector valve configured to switch between a plurality of solvents to be aspirated and discharged, and a controller configured to control the liquid feeder and the selector valve. The controller controls the selector valve in synchronization with an aspiration operation of the plunger so that a mixing ratio of the solvents changes, controls the plunger to cause the plunger to operate at first and second accelerations that are different from each other, and suppresses a fluctuation of the solvent to be aspirated by the plunger.

Liquid feeding apparatus and liquid feeding method

Provided is a technique for accurately determining a performance of a single detector that detects ions having passed through a mass analysis unit. A mass analysis system according to the present disclosure includes, in a mass analysis device, a first converter configured to calculate a first measured value based on an intensity and an area of a pulse in an electric signal output from the detector configured to detect the ions having passed through the mass analysis unit, a second converter configured to obtain a second measured value by counting the number of pulses of the electric signal, a calculation unit configured to calculate an A/P ratio indicating a ratio of the first measured value to the second measured value, a determination unit configured to determine a performance of the detector based on a value of the A/P ratio, and a control unit configured to control at least an output of a determination result obtained by the determination unit.

Mass analysis system, and method for determining performance of mass analysis device

There is provided a mass spectrometer that can appropriately maintain the atmospheric pressure of a vacuum chamber, and a method of controlling the same. An example of a mass spectrometer according to the present invention includes first vacuum chambers, first vacuum pumps, an atmospheric pressure relating value acquiring unit, and an adjustment unit configured to adjust the effective exhaust velocity of the first vacuum pumps, and controllers. The controllers control the adjustment unit corresponding to an atmospheric pressure relating value.

Mass spectrometer and method of controlling the same

Growing community of inventors

Tachikawa, Japan

Yuichiro Hashimoto