Takeda Pharmaceutical Company Limited

Yuichiro Amano

Daisuke Tomita

Junichi Sakamoto

Hiroshi Banno

Shigekazu Sasaki

Hironobu Maezaki

Michiko Tawada

Noriyuki Nii

Ryo Mizojiri

Moriteru Asano

Krista E Gipson

Kohji Fukatsu

Kazumasa Hamamura

Shuntarou Tsuchiya

Mayumi Imai

Shuntaro Tsuchiya

The present invention relates to a compound which may be useful as an agent for the prophylaxis or treatment of cancer, hepatitis, hepatic fibrosis, fatty liver and the like.

Monocyclic compound

The present invention provides a compound represented by the formula (I): [wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, p is 0, 1 or 2, and when p is 2, each R may be the same or different, Ris a hydrogen atom or an optionally substituted hydrocarbon group, Ris an optionally substituted aromatic group, Ring A is an optionally substituted monocyclic aromatic ring or optionally substituted bicyclic aromatic fused ring, Xis an oxygen atom or a sulfur atom, Xis a bond, an oxygen atom or &#x2014;S(O)&#x2014; (wherein n is 0, 1 or 2), Y is a bond, an oxygen atom, &#x2014;S(O)&#x2014;, &#x2014;C(&#x2550;O)&#x2014;N(R)&#x2014; or &#x2014;N(R)&#x2014;C(&#x2550;O)&#x2014; (Ris a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, and m is 0, 1 or 2), M, Mand Mmay be the same or different and are each independently a bond or an optionally substituted divalent aliphatic hydrocarbon group, and Mis an optionally substituted divalent aliphatic hydrocarbon group] or a salt thereof, which is useful as a prophylactic and/or therapeutic agent for lipid metabolism abnormality, arteriosclerotic disease and sequelae thereof, diabetes mellitus and the like.

Furan or thiophene derivative and medicinal use thereof

Growing community of inventors

Kanagawa, Japan

Yuichiro Amano