Daiichi Sankyo Company, Limited

Daiichi Pharmaceutical Co., Ltd.

Msd K.k.

Yuichi Sugimoto

Hiroyuki Takahashi

Toshiyuki Watanabe

Atsushi Nakayama

Tadashi Shimamura

Teruyuki Nishimura

Katsuhiro Kawakami

Shin Iimura

Hiroshi Takeshita

Takao Horiuchi

Nobuo Machinaga

Jun Chiba

Junichi Kuroyanagi

Yoshiyuki Yoneda

Keisuke Arakawa

Syozo Kobayashi

Issei Achiwa

Kazuo Kanai

The present invention relates to a compound represented by formula (I): (wherein R, R, Rand Reach independently represent a hydrogen or halogen atom; Rand Reach independently represent a hydrogen atom or lower alkyl or together represent oxo; X represents C(O) or the like; Y represents an oxygen atom or the like; Z represents a hydrogen atom or the like; R represents 5- or 6-membered heteroaryl having 1-3 hetero atoms selected from the group consisting of nitrogen, sulfur and oxygen atoms, contained within a ring, or the like) or to a pharmaceutically acceptable salt thereof. 

Isoindolin-1-one derivative

A 1,6-&#x3b2;-glucan synthetase inhibitor is provided, having potent growth inhibition and having excellent safety. A compound is provided, capable of expressing in a wide spectral range and specifically or selectively, an antifungal effect based on its functional mechanism of 1,6-&#x3b2;-glucan synthesis inhibition. Also provided is a drug, a salt or hydrate thereof, especially an antifungal that contains the compound. Concretely, provided is a compound of the following formula (I), its salt or hydrate, and a drug or antifungal containing, as the active ingredient, the compound, its salt or hydrate: 

Antifungal bicyclic hetero ring compounds

The present invention relates to a compound represented by the following formula (I): (wherein, W represents W-A-W- (in which, Wis substituted or unsubstituted aryl, etc., Ais &#x2014;NR&#x2014;, single bond, &#x2014;C(O)&#x2014;, etc., and Wis substituted or unsubstituted arylene, etc.), R is single bond, &#x2014;NH&#x2014;, &#x2014;OCH&#x2014;, alkenylene, etc., X is &#x2014;C(O)&#x2014;, &#x2014;CH&#x2014;, etc., and M is, for example, the following formula: (in which, R, Rand Reach independently represents hydrogen, hydroxyl, amino, halogen, etc., Ris hydrogen or lower alkyl, Y represents &#x2014;CH&#x2014;O&#x2014;, etc., Z is substituted or unsubstituted arylene, etc., Ais single bond, etc, and Ris hydroxyl or lower alkoxy)), or salt thereof; and a medicament containing the same. This compound or salt thereof selectively inhibits binding of cell adhesion molecules to VLA-4 and exhibits high bioavailability so that it is useful as a preventive and/or remedy for inflammatory diseases, autoimmune diseases, metastasis, bronchial asthma, rhinostenosis, diabetes, and the like.

Vla-4 inhibitors

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Tokyo, Japan

Yuichi Sugimoto