Konica Minolta Opto, Inc.

Konica Minolta, Inc.

Konica Minolta Business Technologies, Inc.

Yuichi Ozaki

Eigo Sano

Kensaku Takanashi

Yasushi Nakano

Masaru Takahashi

Kohsuke Gonda

Noriaki Ohuchi

Hisatake Okada

Mika Watanabe

Hideki Gouda

Takashi Kawasaki

Atsushi Yamashita

Kazuki Matsui

Yuka Yoshihara

Norikazu Masuda

Masakazu Toi

Hiroshi Tada

Minoru Miyashita

Daisuke Tomioka

A biological substance quantification method of quantifying an expression amount of a specific biological substance in a target sample stained by using a fluorescent dye accumulated particle bondable to the specific biological substance. The method includes: inputting a first fluorescent image obtained by image capturing of the target sample; extracting a bright spot portion from the first fluorescent image and calculating a first luminance value; and calculating a number of the fluorescent dye accumulated particle included in the bright spot portion by using the first luminance value, a second luminance value of a bright spot portion extracted from a second fluorescent image obtained by image capturing of a standard sample, and a distribution of a third luminance value of each bright spot portion in a third fluorescent image obtained by image capturing of a preparation on which the fluorescent dye accumulated particle is dispersed without aggregating.

Biological substance quantification method, image processing device, pathological diagnosis support system, and recording medium storing computer readable program

The present invention relates to a test support method which is a means for predicting whether or not pathological complete response (pCR) will be attained when a preoperative chemotherapy with an anticancer drug is performed, the method using a sample (breast cancer tissue section) collected from a breast cancer patient to be subjected to the preoperative chemotherapy. The test support method includes: [1] the step of acquiring a fluorescence image of a breast cancer tissue section, which fluorescence image shows bright spots of fluorescent nanoparticles labeling one or more kinds of breast cancer-related proteins; [2] the step of acquiring at least one index relating to the expression level(s) of the breast cancer-related protein(s) on the basis of the bright spots of the fluorescence image; and [3] the step of acquiring information for predicting pCR by performing an analysis using the above-described at least one index.

Test support method for supporting prediction of pathological complete response (pCR) using fluorescent nanoparticles

A method of quantifying a specific biological material in a specimen stained using fluorescent dye accumulating particles capable of binding to the material includes: inputting a first fluorescence image obtained by capturing an image of the specimen; extracting a certain region from the first fluorescence image and calculating a first luminance integrated value by integrating luminance values of the certain region; and calculating the number of the particles included in the certain region from the first luminance integrated value and an average luminance value per fluorescent dye accumulating particle, wherein the average luminance value is calculated from a distribution of second luminance integrated values obtained by integrating luminance values for individual bright spot regions, which indicate emission of light by the fluorescent dye accumulating particles, in a second fluorescence image obtained by capturing an image of a preparation onto which the fluorescent dye accumulating particles are dispersed without agglomerating.

Biological material quantifying method, image processing device, pathological diagnosis support system and recording medium

A first lens group includes a plano-concave and negative first lens, a catoptric element having a flat object side surface and a flat image side surface, and a first cemented lens, for example. Here, the first cemented lens includes a negative second lens and a positive third lens in order from an object side. A second lens group includes an aperture stop and a positive second cemented lens, for example. The second cemented lens includes a positive fourth lens, a negative fifth lens, and a positive sixth lens in order from the object side. A zoom lens satisfies a conditional expression 1.59&#x3c;n&#x3c;2.20, assuming that a value nindicates refractive index of the fourth lens on a side closest to an object in the second lens group.

Zoom lens and image pickup device

A zoom lens has first through fourth lens groups from the object side to the image side, and changes the magnification by changing their intervals. The first and third lens groups and the second and fourth lens groups have negative and positive powers, respectively. When changing the magnification from the wide-angle end to the telescopic end, the interval between the first and the second lens groups is reduced. The first lens group includes a reflective optical element. The second lens group includes at least two lenses, and the lens nearest to the image is a single plastic positive lens. The third lens group is configured by a single plastic negative lens. When the focal length of the single lens nearest to the image in the second lens group is defined as f2L and the focal length of the third lens group is defined as f3, '0.60&#x3c;|f2L/f3|&#x3c;1.60' is satisfied.

Zoom lens and imaging device

Disclosed are an image pickup lens which provides a sufficient back focus and can be subjected to a reflow process while offering a capability to be used with either a 1/10-inch-sized or a 1/12-inch-sized solid-state image pickup device, as well as an image pickup apparatus and a portable terminal employing such an image pickup lens. An image pickup lens for focusing an image of a subject on a photoelectric converting portion of a solid-state image pickup device, the image pickup lens comprising an aperture stop and a single lens arranged in this order from an object side, wherein the image pickup lens satisfies the following conditional formulae:0.70 mm&#x3c;&#x3c;1.60 mm&#x2003;&#x2003;(1)0.70&#x3c;(1+2)/(1&#x2212;2)&#x3c;1.60&#x2003;&#x2003;(2)where

Image pickup lens, image pickup apparatus and portable terminal

Provided is a small-sized five-element image pickup lens which ensures a sufficient lens speed of about F2 and exhibits various aberrations being excellently corrected. The image pickup lens is composed of, in order from the object side, a first lens with a positive refractive power, including a convex surface facing the object side; a second lens with a negative refractive power, including a concave surface facing the image side; a third lens with a positive or negative refractive power; a fourth lens with a positive refractive power, including a convex surface facing the image side; and a fifth lens with a negative refractive power, including a concave surface facing the image side. The image-side surface of the fifth lens has an aspheric shape, and includes an inflection point at a position excluding an intersection point with the optical axis.

Imaging lens, imaging device and portable terminal

The image pickup lens is composed of, in order from the object side, an aperture stop; a first lens with positive refractive power, including a convex surface facing the object side; a second lens with negative refractive power, including a concave surface facing an image side; a third lens with positive refractive power, including a convex surface facing the image side; a fourth lens with positive refractive power, having a meniscus shape including a convex surface facing the image side; and a fifth lens with negative refractive power, including a concave surface facing the image side. The image pickup lens satisfies conditional expressions relating to curvature radiuses of the object-side surface and the image-side surface of the fourth lens, a distance on an optical axis from the aperture stop to a focal point at the image side, and a focal length of the total system of the image pickup lens.

Image pickup lens, image pickup apparatus, and mobile terminal

Image pickup lens, image pickup apparatus and mobile terminal

Provided is a method for designing an image pickup lens which is low cost and applicable to reflow process. The method includes a step of designing the image pickup lens including a lens formed of energy curable resin, on the assumption that the energy curable resin is homogeneous; a step of obtaining an image pickup lens by manufacturing each lens forming the image pickup lens, based on the design; a step of evaluating lens performance of the obtained image pickup lens; a step of designing the image pickup lens again by changing surface shape of at least one surface and/or lens-surface distance in at least one place in the image pickup lens, based on the lens performance obtained by an simulation in the designing step and the lens performance of the image pickup lens obtained in the evaluating step.

Method for designing imaging lens, and imaging lens

An imaging lens good in mass-productivity, compact, low in manufacturing cost, good in aberration performance is provided by effectively correcting aberrations without greatly varying the variation of the thickness of a curing resin. An imaging device having such an imaging lens and a portable terminal are also provided. A third lens (L) has a flat surface on the object side, a convex surface near the optical axis on the image side, and a concave aspheric surface around the peripheral portion within the region where a light beam passes. Therefore, it is possible to reduce the other optical aberrations such as distortion and simultaneously to design the imaging lens so that the astigmatism takes on a maximum value at the outermost portion. Hence, the resolutions at low to middle image heights are high. In addition, such a shape does not cause a large variation of the thickness of the third lens (L) from the region along the axis to the periphery. Therefore, the thickness of the third lens (L) can be small, and the material cost can be reduced.

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Hachioji, Japan

Yuichi Ozaki