Taiho Pharmaceutical Company Limited

Yuichi Kawai

Shuichi Ohkubo

Makoto Kitade

Takeshi Sagara

Takao Uno

Hiromi Oshiumi

Chihoko Yoshimura

Kazutaka Miyadera

Satoshi Yamashita

Hiroki Irie

To provide a novel compound having a HER2 inhibitory effect and having a cytostatic effect. It is also intended to provide a medicament useful in the prevention and/or treatment of a disease involving HER2, particularly, cancer, on the basis of the HER2 inhibitory effect. The present invention provides a compound of formula (I) wherein X, Y, Z, Z, Z, Z, W, n, R, R, and Rhave meanings as defined in the present specification, or a salt thereof. 

Pyrazolo[3,4-d]pyrimidine compound or salt thereof

It is intended to provide a novel azabicyclo compound which exhibits both HSP90 inhibitory activity and cell proliferation inhibitory effect. Specifically disclosed is a compound represented by the following general formula (I) or a salt thereof: wherein Xrepresents CH or N; any one of X, Xand Xrepresents N, and the others represent CH; any one or two of Y, Y, Yand Yrepresent C&#x2014;R, and the others are the same or different and represent CH or N; Rrepresents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S and O; Rrepresents an alkyl group having 1 to 6 carbon atoms, or the like; and Rand Rrepresent &#x2014;CO&#x2014;Ror the like.

Azabicyclo compound and salt thereof

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Tsukuba, Japan

Yuichi Kawai