Theravance Biopharma R&d Ip, LLC

Praxis Bioresearch, LLC

YuHua Ji

YongQi Mu

Craig Husfeld

Li Li

Mathai Mammen

Daniel D Long

Daniel Marquess

Valentino J Stella

Rick Andrew Lee

Ron H Bihovsky

Steven A Smith

Sandeep Patil

Cameron Smith

Johnny Uy

Ron Bihovsky

Steve Smith

This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar, R, R, R, R, R, R, and Rare as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

Biphenyl compounds useful as muscarinic receptor antagonists

Disclosed herein are pharmaceutical compositions comprising fencamfamine or fencamfamine related prodrug derivatives for targeted therapeutic applications and methods of synthesizing the compositions.

Prodrugs of fencamfamine

Disclosed herein are pharmaceutical compositions with fencamfamine or fencamfamine related prodrug derivatives. The pharmaceutical compositions are for targeted therapeutic applications including, but not limited to, treating cancer-related fatigue, apathy in Alzheimer's Disease, major depression, and attention deficit-hyperactivity disorder. Also disclosed are methods of synthesizing the pharmaceutical compositions with fencamfamine or fencamfamine related prodrug derivatives.

The invention provides compounds of the formula: in salt or zwitterionic form or a pharmaceutically acceptable salt thereof, wherein R, a, Z and Q are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.

Quaternary ammonium compounds useful as muscarinic receptor antagonists

The invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein R, R, a, X, Y, Y', Y&#x2033;, and Z are as defined in the specification. These compounds are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes for preparing such compounds and methods of using such compounds to, for example, treat pulmonary disorders such as chronic obstructive pulmonary disease and asthma.

Guanidine-containing compounds useful as muscarinic receptor antagonists

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Palo Alto, CA, United States of America

YuHua Ji