Shanghai Jiao Tong University

Other

Changzhou Bio-sheng Technology Co., Ltd

Pan Asia Bio Co., Ltd.

Vaxgene Corporation

Yuhong Xu

Jipin Zhong

Xiaolong Chen

Jiang Chang

Yangsheng Qiu

Dominic Man-Kit Lam

Yongxiang Wang

Junlian Huang

Michael Min Xu

Xiaojian Hu

Dan Liu

Xiaohui Wei

Anjie Zheng

Jianrong Xu

Shuxian Song

The present disclosure relates to an all-trans retinoic acid liposome formulation and a preparation method thereof. The all-trans retinoic acid liposome formulation includes all-trans retinoic acid and a liposome vector. The disclosure adopts an active drug loading method, including a calcium acetate gradient method or a sodium acetate gradient method. The prepared all-trans retinoic acid formulation has high drug loading and high stability in vivo, thereby increasing the blood concentration and prolonging the half-life of the all-trans retinoic acid.

All-trans retinoic acid liposome formulation, and preparation and use thereof

Provided in the present invention are a monoclonal antibody FnAb8 and application thereof.

Monoclonal antibody FnAb8 and application thereof

The present invention relates to a pH buffered bioactive glass, and its preparation process and use. The pH buffered bioactive glass comprises SiO, CaO, NaO, and PO, and further comprises solid acidic particles or a Tris buffer solution. The pH buffered bioactive glass can regulate the pH of formulations comprising bioactive glass, and has a good therapeutic effect with a low dosage.

pH buffered bioactive glass, and its preparation process and use

An aqueous negative contrast agent for CT imaging of the gastrointestinal tract and the preparation method thereof. The agent is used in biological and pharmaceutical field. Its components and the weight percent are: hydrogel matrix 0.01-1%, micro-/nano-particles of the materials with low densities 5-50%, stabilization agents 0.1-5%, the rest is deionized water. The preparation method is: stabilization agents are added into the hydrogel matrix made of natural or synthetic hydrophilic polymers, then micro-/nano-particles of the materials with low CT densities are added or prepared, and uniformly dispersed in the hydrogel matrix. The CT density of the resulted aqueous negative contrast agent for CT imaging of the gastrointestinal tract is &#x2212;30 HU to &#x2212;500 HU. It can decrease the CT density inside the intestine lumen to lower than &#x2212;30 HU. The intestine wall can be depicted clearly and the CT signals intensities inside lumen are uniform. It is feasible for 3D images processing such as virtual endoscopy reconstruction with the negative contrast agent. The agent is safe, stable and nontoxic. It will not lead to diarrhea after administration. It is of great significance for the improved sensitivity and specificity of CT diagnosis for the diseases on the intestinal wall and lumen.

Aqueous negative contrast medium for CT imaging of the gastrointestinal tract and the preparation method thereof

Multi-armed functional polyethylene glycol polymers with active terminal groups may be used in conjugation with small molecule pharmaceuticals, proteins and peptides to enhance half-life and bioavailability of the drug and improve solubility, stability and immunological competence.

Multidrop tree branching functional polyethylene glycol, methods of preparing and using same

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Shanghai, China

Yuhong Xu