Shiseido Company, Limited

Yuhei Iwata

Kiyoshi Miyazawa

Shuya Tamaki

Uhei Tamura

Isao Murotani

Tadahiro Chiba

Kazuo Akima

Nobutoshi Watari

Kayoko Matsuo

A compound of hyaluronic acid and a medicinal ingredient produced by the convalent bonding (preferably amide bonding) of hyaluronic acid and the medicinal ingredient, and a process for preparing the same. The hyaluronic acid portion is completely decomposed by metabolism in the action region, whereby the medicinal ingredient is gradually and quantitatively released.

Compound for medicinal ingredient and hyaluronic acid and process for

A percutaneous absorption promoting agent comprising (A) at least one anionic surfactant and one or two or more of surfactants having a nitrogen atom in the molecule other than anionic surfactants, (B) one or two or more of anionic surfactants and one or two or more of nonionic surfactants not having a nitrogen atom in the molecule, (C) one or two or more of surfactants selected from the group consisting of amphoteric surfactant and semi-polar surfactants and at least one nonionic surfactant having a nitrogen atom in the molecule, (D) one or two or more of surfactants selected from the group consisting of nonionic surfactants, amphoteric surfactants, semi-polar surfactants and cationic surfactants having a nitrogen atom in the molecule, and one or two or more of nonionic surfactants not having a nitrogen atom in the molecule, or (E) an amine oxide as the active ingredient, and a dermatological preparation containing these percutaneous absorption promoting agent and drug components.

Percutaneous absorption promoting agent and dermatologic preparation

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Yokohama, Japan

Yuhei Iwata