Industrial Technology Research Institute

Bio Preventive Medicine Corp.

Yuh-Feng Ling

Ping-Fu Cheng

Tzu-Ling Tseng

Wei-Ya Lin

Tsai-Wei Hsu

Yen-Peng Li

Mary Ya-Ping Yeh

Hung-Yi Li

Yi-Ting Chen

Jin-Shuen Chen

Described is a method of detecting a protein fragment in a urine sample and a serum sample. The protein fragment is a urine precursor alpha-2-HS-glycoprotein, urine alpha-1 antitrypsin, urine alpha-1 acid glycoprotein, urine osteopontin, or serum osteopontin fragment. The urine sample and the serum sample are obtained from the same individual.

Method of detecting a urine protein fragment and a serum protein fragment

Disclosed is use of urine and serum biomarkers in diagnosing diabetic nephropathy, staging diabetic nephropathy, monitoring diabetic nephropathy progress, and assessing efficacy of diabetic nephropathy treatments. These biomarkers include urine precursor alpha-2-HS-glycoprotein, urine alpha-1 antitrypsin, urine alpha-1 acid glycoprotein, urine osteopontin, serum osteopontin, their fragments, and combinations thereof.

Urine and serum biomarkers associated with diabetic nephropathy

Growing community of inventors

Taipei, Taiwan

Yuh-Feng Ling