Chugai Seiyaku Kabushiki Kaisha

H. Lundbeck A/s

Yugo Ikeda

Minoru Shindo

Tamotsu Yamazaki

Yasuhiro Ohba

Shun-Ichi Hata

Kazushige Sakai

Yasuo Fujimura

Morio Kakimoto

Sadao Tanaka

Yasuyuki Shiraki

Isao Matsunaga

Yoshiaki Tanaka

Hiroyuki Nagano

Naomi Kobayashi

Fujimura Yasuo

Tadashi Kurimoto

Matsunaga Isao

Tsuneo Iwasaki

Tanaka Sadao

A method for the treatment of dementia and cerebrovascular disorders and for inhibiting platelet aggregation in patients in need thereof comprising the step of administering a therapeutically effective amount of a 1-[3-(dimethylamino)propyl]-1-phenylphthalane of the general formula ##STR1## wherein R.sup.1 and R.sup.2 each are selected from the group consisting of halogen, trifluoromethyl, cyano and R--CO--, wherein R is an alkyl radical, or a pharmaceutically-acceptable acid addition salt thereof, is described.

Treatment of cerbrovascular disorders

Pyrazoloindazole derivatives of the formula: ##STR1## [wherein R.sub.1 is a cyano group, carboxy group, a lower alkoxycarbonyl group or a group ##STR2## (wherein R.sub.2 and R.sub.3 are each a hydrogen atom, a lower alkyl group, a phenyl group which may have a substituent or when taken together with a nitrogen atom, form a heterocyclic ring); X.sup..crclbar. is a counter ion], a process for preparing the same and a pharamaceutical composition containing the same are disclosed. The compounds of the formula above have bronchodilating action and are useful as a medicine.

Pyrazoloindazole derivatives and pharmaceutical composition containing

Novel pyrazoloindazole derivatives of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxyl group or benzyloxyl group; R.sub.2 is a hydrogen atom, a halogen atom, a lower alkyl group or phenyl group (provided R.sub.1 and R.sub.2 are not hydrogen at the same time); and X.sup..crclbar. is a halide ion, a hydroxide ion, a methanesulfonate ion, a p-toluene sulfonate ion, a sulfate ion, a nitrate ion, a carbonate ion, an acetate ion, a benzoate ion or a salicylate ion, a process for preparing the derivatives, and a pharmaceutical composition containing the same are disclosed. The derivatives have good bronchodilating action for human without exhibiting substantially bad effects on the functioning of heart, and therefore, they are useful as a drug.

Pyrazoloindazole derivatives and bronchodilating composition

Benzazocine derivatives represented by the formula ##STR1## which have an excellent analgesic action and are useful for use in drugs, and a process for preparing the same are disclosed.

Benzazocine derivatives and process for preparing the same

Indazole derivatives represented by the formula ##SPC1## Wherein X is hydrogen, halogen atom or lower alkyl group; R and R' each is hydrogen, lower alkyl group or lower alkenyl group and when taken together with the nitrogen atom to which they are attached form an unsubstituted or substituted heterocyclic ring; and n is an integer of 1 - 3 are novel compounds having tranquilizing activity, antidepressive activity, anti-inflammatory activity, circulatory activity etc. and are useful as medicines.

1-Aminoalkyl, 3-phenyl indazoles

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Tokyo, Japan

Yugo Ikeda