East China University of Science and Technology

Chinese Academy of Sciences

Other

Dalian University of Technology

Tao Pharmaceutical (suzhou) Co. Ltd

Yufang Xu

Honglin Li

Zhenjiang Zhao

Jing Liu

Wei Zhou

Xuhong Qian

Wenlin Song

Shiliang Li

Lei Zhang

Jian Ding

Jia Tao Li

Hualiang Jiang

Hong Iris Zhu

Jingya Li

Zehong Miao

Xia Wang

Xiaofeng Liu

Zhuo Chen

Yi Tong

Zhuo Fan Chen

Ke Xu

Deheng Sun

Liping Lin

Lili Zhu

Fang Bai

Yinchu Shen

Mengzhu Xue

Youli Zhang

Jia Li

Yonggang Li

Jianjun Fu

Qian Jiao

Liuxin Xu

Baoyuan Qu

Yuqiong Xu

Wanqi Wang

Yingfang Yang

Hongling Xu

The present invention provides a compound as represented by formula I, or a pharmaceutically acceptable salt or ester, a prodrug, an optical isomer, a stereoisomer, or a solvate thereof. The compound provided by the present invention can be used for preparing drugs for preventing or treating hypertension, or hypertension-related diseases, or pulmonary hypertension, or pulmonary hypertension-related diseases. The compound provided by the present invention has a different mechanism from existing drugs for treating hypertension and pulmonary hypertension, thereby laying a new material foundation for the development of drugs for treating hypertension and pulmonary hypertension.

Antihypertensive polyol compound and derivative thereof

Provided are applications of a thiazole derivative in treating virus infection and in the preparation of drugs for treating virus infection. Specifically, provided are applications of a compound represented by formula (I) and a pharmaceutical composition comprising the compound represented by formula (I) in treating virus infection and in the preparation of drugs for treating virus infection: 

Applications of novel thiazole derivative in treating virus infection

The present invention relates to applications of a novel thiazole derivative in treating ulcerative colitis and in the preparation of drugs for treating ulcerative colitis. The present invention specifically relates to applications of a compound represented by formula I and a pharmaceutical composition containing the compound represented by formula I, in treating ulcerative colitis and in the preparation of drugs for treating ulcerative colitis: 

Applications of novel thiazole derivative in treating inflammatory bowel diseases

The present invention relates to a pteridinone derivative serving as an EGFR inhibitor and use thereof. Specifically, the present invention relates to a compound represented by the following formula I, pharmaceutical composition comprising the compound of the following formula I, and use of the compound in preparation of drugs for treating EGFR-mediated diseases or inhibiting EGFR. 

Use of pteridinone derivative serving as EGFR inhibitor

A thiazole derivative serving as a DHODH inhibitor, and applications thereof. The present invention specifically relates to a compound represented by formula I, a pharmaceutical composition containing the compound represented by formula (I), and applications of the compound in the preparation of drugs for treating diseases mediated by the DHODH or drugs for inhibiting the DHODH. 

Thiazole derivative and applications

The present invention relates to six-membered ring benzo derivatives as a DPP-4 inhibitor and a use thereof. In particular, the present invention relates to a compound as shown in formula I, a pharmaceutical composition containing the compound as shown in formula I and a use of the compound in the preparation of drugs for treating DPP-4 related diseases or inhibiting DPP-4. 

Six-membered ring benzo derivatives as DPP-4 inhibitor and use thereof

Provided are a pteridine ketone derivative used as an EGFR, BLK, and FLT3 inhibitor and applications thereof. Specifically, provided are a compound of the following formula I, a pharmaceutical composition containing the compound of the formula I, and use of compound in preparing medicine for treating diseases mediated by EGFR, BLK, or FLT3 or inhibiting EGFR, BLK, and FLT3.

Pteridine ketone derivative and applications thereof as EGFR, BLK, and FLT3 inhibitor

The invention discloses novel sulfur-containing naphthalimide derivatives, and the preparation and uses thereof. The conjugated plane of naphthalimide derivatives of the invention is enlarged by incorporating 5-or 6-membered heteroaromatic ring and/or introducing S heteroatom, thus increasing the anti-tumor activity of naphthalimide. The compounds of the invention displays significant inhibiting activities to the proliferation of various tumor cells such as human lung cancer, gastric cancer, liver cancer, leucocythemia and the like. The inhibition of cell proliferation is dose-dependent.

Sulfur-containing naphthalimide derivatives

Growing community of inventors

Shanghai, China

Yufang Xu